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Trpm4 Gene Detail
Summary
  • Symbol
    Trpm4
  • Name
    transient receptor potential cation channel, subfamily M, member 4
  • Synonyms
    1110030C19Rik, LTRPC4, TRPM4B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915917
    NCBI Gene: 68667
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44952579-44983495 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915917
 protein coding gene Chr7:44952056-44983495 (-)
129S1/SvImJ ENSMUSG00200026758
 protein coding gene Chr7:32550727-32551494 (-)
129S1/SvImJ ENSMUSGG00200054434
 protein coding gene Chr7:32572694-32580007 (-)
A/J ENSMUSGG00195054929
 protein coding gene Chr7:36603671-36610975 (-)
A/J ENSMUSG00195047264
 protein coding gene Chr7:36580932-36592916 (-)
AKR/J ENSMUSG00220008007
 protein coding gene Chr7:30882326-30894316 (-)
AKR/J ENSMUSGG00220054812
 protein coding gene Chr7:30905060-30912372 (-)
BALB/cJ ENSMUSG00180028741
 protein coding gene Chr7:33456338-33468322 (-)
BALB/cJ ENSMUSGG00180055575
 protein coding gene Chr7:33479081-33486391 (-)
C3H/HeJ ENSMUSGG00175054613
 protein coding gene Chr7:34008626-34015945 (-)
C3H/HeJ ENSMUSG00175036272
 protein coding gene Chr7:33985886-33997868 (-)
C57BL/6NJ ENSMUSGG00215055228
 protein coding gene Chr7:33268805-33276111 (-)
C57BL/6NJ ENSMUSG00215039915
 protein coding gene Chr7:33246071-33258060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029710
 protein coding gene Chr7:47242633-47271509 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210045445
 protein coding gene Chr7:34357230-34369223 (-)
CBA/J ENSMUSGG00210055067
 protein coding gene Chr7:34379968-34387285 (-)
DBA/2J ENSMUSGG00185057917
 protein coding gene Chr7:38255450-38262756 (-)
DBA/2J ENSMUSG00185044282
 protein coding gene Chr7:38232710-38244693 (-)
FVB/NJ ENSMUSGG00205054628
 protein coding gene Chr7:33924345-33931671 (-)
FVB/NJ ENSMUSG00205046871
 protein coding gene Chr7:33901608-33913601 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055862
 protein coding gene Chr7:43681932-43689279 (-)
NOD/ShiLtJ ENSMUSGG00190055081
 protein coding gene Chr7:34252068-34259388 (-)
NOD/ShiLtJ ENSMUSG00190045030
 protein coding gene Chr7:34229332-34241322 (-)
NZO/HlLtJ ENSMUSGG00225055565
 protein coding gene Chr7:41892804-41900099 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010028818
 protein coding gene Chr7:32960896-32990727 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TRPM4, transient receptor potential cation channel subfamily M member 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPM4, transient receptor potential cation channel subfamily M member 4
  • Synonyms
    EKVP6, hTRPM4, LTrpC4, PFHB1B, TRPM4B
  • Links
    NCBI Gene ID: 54795
    UniProt: Q8TD43

  • Chr Location
    19q13.33; chr19:49157741-49211836 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TRPM4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display increased Ca2+ influx and IgE-dependent mast cell activation, increased vascular permeability, and enhanced acute anaphylactic responses. Mice homozygous for a different knock-out allele show Ca2+ overload and impaired dendritic cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    16
  • cDNA Data
    44
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68667 NCBI Gene Model | MGI Sequence Detail 30917 C57BL/6J ±  kb
    transcript NM_175130 RefSeq | MGI Sequence Detail 4257 C57BL/6  
    polypeptide Q7TN37 UniProt | EBI | MGI Sequence Detail 1213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142190
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:357514 Yan J, et al., TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS. Cell Rep Med. 2024 Feb 20;5(2):101413
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory