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Mtcl1 Gene Detail
Summary
  • Symbol
    Mtcl1
  • Name
    microtubule crosslinking factor 1
  • Synonyms
    1110012J17Rik, mKIAA0802, Soga2, t8219b25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915867
    NCBI Gene: 68617
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66643977-66756745 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3604 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915867
 protein coding gene Chr17:66643975-66760672 (-)
129S1/SvImJ ENSMUSG00200037931
 protein coding gene Chr17:61985241-62098143 (-)
A/J ENSMUSG00195017704
 protein coding gene Chr17:63327531-63440435 (-)
AKR/J ENSMUSG00220017832
 protein coding gene Chr17:62407295-62520075 (-)
BALB/cJ ENSMUSG00180019431
 protein coding gene Chr17:63064909-63177753 (-)
C3H/HeJ ENSMUSG00175027352
 protein coding gene Chr17:62372370-62485265 (-)
C57BL/6NJ ENSMUSG00215017067
 protein coding gene Chr17:62032166-62144956 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021838
 protein coding gene Chr17:62480625-62592039 (-)
CAST/EiJ ENSTCUG00005025431
 protein coding gene Chr17:62987992-63102244 (-)
CBA/J ENSMUSG00210029522
 protein coding gene Chr17:62172293-62285187 (-)
DBA/2J ENSMUSG00185022528
 protein coding gene Chr17:65016786-65129673 (-)
FVB/NJ ENSMUSG00205012132
 protein coding gene Chr17:62791368-62904262 (-)
JF1/MsJ ENSUMUG00000037316
 protein coding gene Chr17:64670814-64783790 (-)
LP/J ENSMUSG00230014607
 protein coding gene Chr17:66003473-66116358 (-)
NOD/ShiLtJ ENSMUSG00190034862
 protein coding gene Chr17:62151258-62264117 (-)
NZO/HlLtJ ENSMUSG00225025599
 protein coding gene Chr17:68280332-68393121 (-)
PWK/PhJ ENSLUMG00010028554
 protein coding gene Chr17:61952644-62074438 (-)
SPRET/EiJ ENSMSPG00010015044
 protein coding gene Chr17:62314640-62427613 (-)
WSB/EiJ ENSIUOG00005030944
 protein coding gene Chr17:63015685-63128501 (-)



Homology
more
  • Human Ortholog
    MTCL1, microtubule crosslinking factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTCL1, microtubule crosslinking factor 1
  • Synonyms
    CCDC165, KIAA0802, SOGA2
  • Links
    NCBI Gene ID: 23255
    UniProt: Q9Y4B5

  • Chr Location
    18p11.22; chr18:8705271-8832780 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    97
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052105 Ensembl Gene Model | MGI Sequence Detail 112769 C57BL/6J ±  kb
    transcript ENSMUST00000086693 Ensembl | MGI Sequence Detail 7221 Not Applicable  
    polypeptide ENSMUSP00000083899 Ensembl | MGI Sequence Detail 1945 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory