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Mocos Gene Detail
Summary
  • Symbol
    Mocos
  • Name
    molybdenum cofactor sulfurase
  • Synonyms
    1110018O12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915841
    NCBI Gene: 68591
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24786748-24834632 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 13.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1686 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915841
 protein coding gene Chr18:24786538-24834634 (+)
129S1/SvImJ ENSMUSG00200015697
 protein coding gene Chr18:21784198-21832150 (+)
A/J ENSMUSG00195002081
 protein coding gene Chr18:21942004-21989937 (+)
AKR/J ENSMUSG00220010800
 protein coding gene Chr18:21938252-21986222 (+)
BALB/cJ ENSMUSG00180003253
 protein coding gene Chr18:22392107-22440082 (+)
C3H/HeJ ENSMUSG00175023597
 protein coding gene Chr18:21905895-21953822 (+)
C57BL/6NJ ENSMUSG00215019419
 protein coding gene Chr18:21643876-21691836 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022053
 protein coding gene Chr18:21640364-21688457 (+)
CAST/EiJ ENSTCUG00005015238
 protein coding gene Chr18:21622887-21673103 (+)
CBA/J ENSMUSG00210015993
 protein coding gene Chr18:21933009-21980891 (+)
DBA/2J ENSMUSG00185021710
 protein coding gene Chr18:21881032-21928907 (+)
FVB/NJ ENSMUSG00205018269
 protein coding gene Chr18:21613307-21661272 (+)
JF1/MsJ ENSUMUG00000022999
 protein coding gene Chr18:21983853-22032554 (+)
LP/J ENSMUSG00230005213
 protein coding gene Chr18:23980069-24028023 (+)
NOD/ShiLtJ ENSMUSG00190006852
 protein coding gene Chr18:21692737-21740655 (+)
NZO/HlLtJ ENSMUSG00225025515
 protein coding gene Chr18:23929166-23977089 (+)
PWK/PhJ ENSLUMG00010003434
 protein coding gene Chr18:22169621-22218054 (+)
SPRET/EiJ ENSMSPG00010021908
 protein coding gene Chr18:22091803-22139879 (+)
WSB/EiJ ENSIUOG00005002587
 protein coding gene Chr18:21713143-21761298 (+)



Homology
more
  • Human Ortholog
    MOCOS, molybdenum cofactor sulfurase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOCOS, molybdenum cofactor sulfurase
  • Synonyms
    HMCS, MCS, MOS
  • Links
    NCBI Gene ID: 55034
    UniProt: Q96EN8

  • Chr Location
    18q12.2; chr18:36186894-36272157 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Mocos mouse models; 1 with human MOCOS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature death, renal failure due to obstructive nephropathy with xanthinuria, xanthine deposits, cystic tubular dilation, Tamm-Horsfall protein deposits, tubular cell necrosis with neutrophils, occasional hydronephrosis with urolithiasis, and altered metabolism of purines, amino acids, and phospholipids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    2
  • cDNA Data
    35
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039616 Ensembl Gene Model | MGI Sequence Detail 47885 C57BL/6J ±  kb
    transcript ENSMUST00000068006 Ensembl | MGI Sequence Detail 2903 Not Applicable  
    polypeptide ENSMUSP00000063609 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory