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Mpzl1 Gene Detail
Summary
  • Symbol
    Mpzl1
  • Name
    myelin protein zero-like 1
  • Synonyms
    1110007A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915731
    NCBI Gene: 68481
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165419809-165462107 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 72.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1249 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915731
 protein coding gene Chr1:165419745-165462144 (-)
129S1/SvImJ ENSMUSG00200042453
 protein coding gene Chr1:162921517-162937653 (-)
129S1/SvImJ ENSMUSGG00200054516
 protein coding gene Chr1:162957306-162962557 (-)
A/J ENSMUSG00195045262
 protein coding gene Chr1:162230101-162246238 (-)
A/J ENSMUSGG00195054887
 protein coding gene Chr1:162265892-162271141 (-)
AKR/J ENSMUSG00220013322
 protein coding gene Chr1:162018657-162034795 (-)
AKR/J ENSMUSGG00220054601
 protein coding gene Chr1:162054445-162059694 (-)
BALB/cJ ENSMUSGG00180055459
 protein coding gene Chr1:162511313-162516562 (-)
BALB/cJ ENSMUSG00180036478
 protein coding gene Chr1:162475523-162491660 (-)
C3H/HeJ ENSMUSG00175041563
 protein coding gene Chr1:162571286-162587422 (-)
C3H/HeJ ENSMUSGG00175054913
 protein coding gene Chr1:162607072-162612317 (-)
C57BL/6NJ ENSMUSGG00215055454
 protein coding gene Chr1:162392971-162398218 (-)
C57BL/6NJ ENSMUSG00215039298
 protein coding gene Chr1:162357181-162373318 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014807
 protein coding gene Chr1:156000042-156041576 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054802
 protein coding gene Chr1:162481592-162486797 (-)
CBA/J ENSMUSG00210020301
 protein coding gene Chr1:162445806-162461942 (-)
DBA/2J ENSMUSG00185010823
 protein coding gene Chr1:166687844-166702983 (-)
FVB/NJ ENSMUSG00205008410
 protein coding gene Chr1:161485458-161501578 (-)
FVB/NJ ENSMUSGG00205054282
 protein coding gene Chr1:161521167-161526411 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055500
 protein coding gene Chr1:166346387-166351636 (-)
LP/J ENSMUSG00230022820
 protein coding gene Chr1:166310597-166326737 (-)
NOD/ShiLtJ ENSMUSGG00190054515
 protein coding gene Chr1:162313364-162318608 (-)
NOD/ShiLtJ ENSMUSG00190036784
 protein coding gene Chr1:162278533-162293743 (-)
NZO/HlLtJ ENSMUSGG00225055224
 protein coding gene Chr1:169932191-169937447 (-)
NZO/HlLtJ ENSMUSG00225004448
 protein coding gene Chr1:169896403-169912540 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MPZL1, myelin protein zero like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPZL1, myelin protein zero like 1
  • Synonyms
    MPZL1b, PZR, PZR1b, PZRa, PZRb
  • Links
    NCBI Gene ID: 9019
    UniProt: O95297

  • Chr Location
    1q24.2; chr1:167721192-167791919 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    21
  • Targeted
    4
  • Genomic Mutations
    2 involving Mpzl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    19 strains or lines available
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. Mice homozygous for a tyrosyl phosphorylation-defective mutant allele display slow postnatal weight gain but have proportionally normal heart weight and morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    62
  • cDNA Data
    154
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026566 Ensembl Gene Model | MGI Sequence Detail 42299 C57BL/6J ±  kb
transcript ENSMUST00000111435 Ensembl | MGI Sequence Detail 2285 Not Applicable  
polypeptide ENSMUSP00000107062 Ensembl | MGI Sequence Detail 270 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 156
    cDNA 154
    Primer pair 2
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:386591 Nguyen J, et al., Progastrin Promotes Colorectal Cancer Stem Cell-Like Properties via the Receptor PZR. Adv Sci (Weinh). 2025 Oct;12(38):e02136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory