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Stt3b Gene Detail
Summary
  • Symbol
    Stt3b
  • Name
    STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
  • Synonyms
    1300006C19Rik, Simp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915542
    NCBI Gene: 68292
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:115071649-115139489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 67.71 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1865 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915542
 protein coding gene Chr9:115071538-115139536 (-)
129S1/SvImJ ENSMUSG00200026582
 protein coding gene Chr9:112169213-112237201 (-)
A/J ENSMUSG00195032753
 protein coding gene Chr9:111353111-111420975 (-)
AKR/J ENSMUSG00220018444
 protein coding gene Chr9:111816558-111884502 (-)
BALB/cJ ENSMUSG00180024676
 protein coding gene Chr9:111890781-111958641 (-)
C3H/HeJ ENSMUSG00175017057
 protein coding gene Chr9:112112730-112180596 (-)
C57BL/6NJ ENSMUSG00215022621
 protein coding gene Chr9:112017178-112085031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032780
 protein coding gene Chr9:110688671-110753079 (-)
CAST/EiJ ENSTCUG00005016305
 protein coding gene Chr9:111783828-111851475 (-)
CBA/J ENSMUSG00210033090
 protein coding gene Chr9:111859551-111927390 (-)
DBA/2J ENSMUSG00185015892
 protein coding gene Chr9:112196280-112264129 (-)
FVB/NJ ENSMUSG00205017914
 protein coding gene Chr9:112013833-112081765 (-)
JF1/MsJ ENSUMUG00000046927
 protein coding gene Chr9:112030838-112098697 (-)
LP/J ENSMUSG00230032315
 protein coding gene Chr9:112293885-112366400 (-)
NOD/ShiLtJ ENSMUSG00190014956
 protein coding gene Chr9:111774340-111842174 (-)
NZO/HlLtJ ENSMUSG00225023104
 protein coding gene Chr9:112567296-112638431 (-)
PWK/PhJ ENSLUMG00010029721
 protein coding gene Chr9:111954495-112022728 (-)
SPRET/EiJ ENSMSPG00010021239
 protein coding gene Chr9:113619266-113688138 (-)
WSB/EiJ ENSIUOG00005021065
 protein coding gene Chr9:111234883-111302874 (-)



Homology
more
  • Human Ortholog
    STT3B, STT3 oligosaccharyltransferase complex catalytic subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STT3B, STT3 oligosaccharyltransferase complex catalytic subunit B
  • Synonyms
    CDG1X, SIMP, STT3-B
  • Links
    NCBI Gene ID: 201595
    UniProt: Q8TCJ2

  • Chr Location
    3p23; chr3:31532521-31638548 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STT3B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth retardation, abnormal head shape, abnormal heart morphology, cardiac and/or pericardial edema, abnormal branchial arches and yolk sacs, placentation defects, and complete lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    16
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032437 Ensembl Gene Model | MGI Sequence Detail 67841 C57BL/6J ±  kb
    transcript ENSMUST00000035010 Ensembl | MGI Sequence Detail 4221 Not Applicable  
    polypeptide ENSMUSP00000035010 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015783 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
      (term hierarchy)
    • EC
      2.4.99.18
    • InterPro Domains
      IPR048307 Oligosaccharyl transferase STT3, N-terminal domain
      IPR003674 Oligosaccharyl transferase, STT3 subunit
      IPR048999 STT3/PglB/AglB, core domain
    • GlyGen
      Q3TDQ1 5 sites, 8 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory