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Agpat4 Gene Detail
Summary
  • Symbol
    Agpat4
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 4
  • Synonyms
    1500003P24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915512
    NCBI Gene: 68262
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12337591-12438532 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.33 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2515 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915512
 protein coding gene Chr17:12337372-12438536 (+)
129S1/SvImJ ENSMUSG00200031146
 protein coding gene Chr17:8563633-8664585 (+)
A/J ENSMUSG00195023521
 protein coding gene Chr17:8770642-8866359 (+)
AKR/J ENSMUSG00220027212
 protein coding gene Chr17:8829108-8930061 (+)
BALB/cJ ENSMUSG00180021962
 protein coding gene Chr17:8412168-8513123 (+)
C3H/HeJ ENSMUSG00175034395
 protein coding gene Chr17:8564045-8659751 (+)
C57BL/6NJ ENSMUSG00215022182
 protein coding gene Chr17:8606824-8707780 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021054
 protein coding gene Chr17:4736263-4837992 (-)
CAST/EiJ ENSTCUG00005021073
 protein coding gene Chr17:8806615-8907789 (+)
CBA/J ENSMUSG00210034325
 protein coding gene Chr17:8227344-8323005 (+)
DBA/2J ENSMUSG00185021935
 protein coding gene Chr17:9320240-9415950 (+)
FVB/NJ ENSMUSG00205008729
 protein coding gene Chr17:8646180-8747086 (+)
JF1/MsJ ENSUMUG00000025203
 protein coding gene Chr17:8902404-8998189 (+)
LP/J ENSMUSG00230020258
 protein coding gene Chr17:10747322-10848258 (+)
NOD/ShiLtJ ENSMUSG00190028747
 protein coding gene Chr17:8748214-8849214 (+)
NZO/HlLtJ ENSMUSG00225047381
 protein coding gene Chr17:12666190-12767131 (+)
PWK/PhJ ENSLUMG00010018800
 protein coding gene Chr17:8742961-8839162 (+)
SPRET/EiJ ENSMSPG00010033640
 protein coding gene Chr17:4813861-4915061 (-)
WSB/EiJ ENSIUOG00005013068
 protein coding gene Chr17:8650871-8751140 (+)



Homology
more
  • Human Ortholog
    AGPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 4
  • Synonyms
    1-AGPAT4, dJ473J16.2, LPAAT4, LPAAT-delta, LPLAT4
  • Links
    NCBI Gene ID: 56895
    UniProt: Q9NRZ5

  • Chr Location
    6q26; chr6:161129967-161274095 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit changes in brain phospholipid content.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    106
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023827 Ensembl Gene Model | MGI Sequence Detail 100942 C57BL/6J ±  kb
    transcript ENSMUST00000024594 Ensembl | MGI Sequence Detail 1915 Not Applicable  
    polypeptide ENSMUSP00000024594 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 46
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:36910 You Y, et al., Chromosomal deletion complexes in mice by radiation of embryonic stem cells. Nat Genet. 1997 Mar;15(3):285-8
    • Latest
      J:371084 Ng KY, et al., AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models. Sci Transl Med. 2025 Jul 30;17(809):eadn9472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory