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Tyw2 Gene Detail
Summary
  • Symbol
    Tyw2
  • Name
    tRNA wybutosine-synthesizing protein 2
  • Synonyms
    4632406N01Rik, Trmt12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915510
    NCBI Gene: 68260
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:58744498-58748630 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915510
 protein coding gene Chr15:58744498-58748976 (+)
129S1/SvImJ ENSMUSG00200028767
 protein coding gene Chr15:55730853-55735305 (+)
A/J ENSMUSG00195006127
 protein coding gene Chr15:55793261-55797714 (+)
AKR/J ENSMUSG00220020364
 protein coding gene Chr15:55767402-55771855 (+)
BALB/cJ ENSMUSG00180008454
 protein coding gene Chr15:55727989-55732442 (+)
C3H/HeJ ENSMUSG00175004696
 protein coding gene Chr15:55979293-55983745 (+)
C57BL/6NJ ENSMUSG00215007864
 protein coding gene Chr15:55710569-55715022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019820
 protein coding gene Chr15:52897980-52902120 (+)
CAST/EiJ ENSTCUG00005006879
 protein coding gene Chr15:55606949-55611407 (+)
CBA/J ENSMUSG00210006992
 protein coding gene Chr15:55807420-55811872 (+)
DBA/2J ENSMUSG00185025622
 protein coding gene Chr15:55768829-55773282 (+)
FVB/NJ ENSMUSG00205006471
 protein coding gene Chr15:55554384-55558836 (+)
JF1/MsJ ENSUMUG00000015546
 protein coding gene Chr15:55569984-55574440 (+)
LP/J ENSMUSG00230007833
 protein coding gene Chr15:59074378-59078830 (+)
NOD/ShiLtJ ENSMUSG00190016907
 protein coding gene Chr15:55788606-55793059 (+)
NZO/HlLtJ ENSMUSG00225028329
 protein coding gene Chr15:59403517-59407970 (+)
PWK/PhJ ENSLUMG00010027869
 protein coding gene Chr15:55850913-55855365 (+)
SPRET/EiJ ENSMSPG00010023009
 protein coding gene Chr15:57054667-57057533 (+)
WSB/EiJ ENSIUOG00005006106
 protein coding gene Chr15:55825355-55829807 (+)



Homology
more
  • Human Ortholog
    TYW2, tRNA wybutosine-synthesizing protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYW2, tRNA wybutosine-synthesizing protein 2
  • Synonyms
    TRM12, TRMT12
  • Links
    NCBI Gene ID: 55039
    UniProt: Q53H54

  • Chr Location
    8q24.13; chr8:124450820-124462150 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68260 NCBI Gene Model | MGI Sequence Detail 4133 C57BL/6J ±  kb
transcript NM_026642 RefSeq | MGI Sequence Detail 4133 Not Specified  
polypeptide Q8BG71 UniProt | EBI | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146013, MGI:8270707
References
more
  • Summaries
    All 52
    Diseases 1
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory