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Wfdc15a Gene Detail
Summary
  • Symbol
    Wfdc15a
  • Name
    WAP four-disulfide core domain 15A
  • Synonyms
    1700049M11Rik, Wfdcl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915471
    NCBI Gene: 68221
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164040783-164042050 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915471
 protein coding gene Chr2:164040783-164042058 (-)
129S1/SvImJ ENSMUSG00200015952
 protein coding gene Chr2:160914183-160915450 (-)
A/J ENSMUSG00195016310
 protein coding gene Chr2:161254339-161255606 (-)
AKR/J ENSMUSG00220013307
 protein coding gene Chr2:160581791-160583058 (-)
BALB/cJ ENSMUSG00180045343
 protein coding gene Chr2:160708084-160709351 (-)
C3H/HeJ ENSMUSG00175046419
 protein coding gene Chr2:161457864-161459131 (-)
C57BL/6NJ ENSMUSG00215023026
 protein coding gene Chr2:160911134-160912401 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024633
 protein coding gene Chr2:156034954-156036204 (-)
CAST/EiJ ENSTCUG00005042943
 protein coding gene Chr2:159821575-159822839 (-)
CBA/J ENSMUSG00210015535
 protein coding gene Chr2:161388833-161390100 (-)
DBA/2J ENSMUSG00185044472
 protein coding gene Chr2:161125062-161126329 (-)
FVB/NJ ENSMUSG00205025125
 protein coding gene Chr2:160146282-160147549 (-)
JF1/MsJ ENSUMUG00000009872
 protein coding gene Chr2:160770932-160772200 (-)
LP/J ENSMUSG00230043346
 protein coding gene Chr2:162683797-162685064 (-)
NOD/ShiLtJ ENSMUSG00190041066
 protein coding gene Chr2:160793672-160794939 (-)
NZO/HlLtJ ENSMUSG00225051870
 protein coding gene Chr2:170687411-170688678 (-)
PWK/PhJ ENSLUMG00010045018
 protein coding gene Chr2:160674892-160676160 (-)
SPRET/EiJ ENSMSPG00010030203
 protein coding gene Chr2:163447160-163447632 (-)
WSB/EiJ ENSIUOG00005040823
 protein coding gene Chr2:160521043-160522310 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes male infertility associated with decreased testis weight, azoospermia, defective spermiogenesis at the beginning of spermatid elongation, increased male germ cell apoptosis, disturbed protease homeostasis, and an orchitis-like inflammatory response in round spermatids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051769 Ensembl Gene Model | MGI Sequence Detail 1268 C57BL/6J ±  kb
    transcript ENSMUST00000063251 Ensembl | MGI Sequence Detail 488 Not Applicable  
    polypeptide ENSMUSP00000070718 Ensembl | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:360881 Tomizawa SI, et al., The non-canonical bivalent gene Wfdc15a controls spermatogenic protease and immune homeostasis. Development. 2024 Sep 15;151(18):dev202834
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory