About   Help   FAQ
Coa8 Gene Detail
Summary
  • Symbol
    Coa8
  • Name
    cytochrome c oxidase assembly factor 8
  • Synonyms
    1700081D05Rik, 2810002N01Rik, Apop-1, Apopt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915270
    NCBI Gene: 68020
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111679695-111721487 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.11 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1345 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915270
 protein coding gene Chr12:111679394-111721491 (+)
129S1/SvImJ ENSMUSG00200025361
 protein coding gene Chr12:103457886-103499689 (+)
A/J ENSMUSG00195041430
 protein coding gene Chr12:105980170-106028414 (+)
AKR/J ENSMUSG00220035023
 protein coding gene Chr12:103867809-103916110 (+)
BALB/cJ ENSMUSG00180046924
 protein coding gene Chr12:105220991-105262805 (+)
C3H/HeJ ENSMUSG00175037642
 protein coding gene Chr12:107784187-107832463 (+)
C57BL/6NJ ENSMUSG00215044963
 protein coding gene Chr12:104493934-104535758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018139
 protein coding gene Chr12:106174562-106212812 (+)
CAST/EiJ ENSTCUG00005038004
 protein coding gene Chr12:103973853-104016007 (+)
CBA/J ENSMUSG00210027365
 protein coding gene Chr12:104845593-104893874 (+)
DBA/2J ENSMUSG00185027679
 protein coding gene Chr12:106675655-106723951 (+)
FVB/NJ ENSMUSG00205032044
 protein coding gene Chr12:103909245-103951575 (+)
JF1/MsJ ENSUMUG00000010624
 protein coding gene Chr12:111452998-111496765 (+)
LP/J ENSMUSG00230042580
 protein coding gene Chr12:113722461-113764249 (+)
NOD/ShiLtJ ENSMUSG00190027795
 protein coding gene Chr12:81284817-81326613 (-)
NZO/HlLtJ ENSMUSG00225042013
 protein coding gene Chr12:115465610-115513707 (+)
PWK/PhJ ENSLUMG00010037107
 protein coding gene Chr12:104906011-104948209 (+)
SPRET/EiJ ENSMSPG00010017900
 protein coding gene Chr12:107192601-107234195 (+)
WSB/EiJ ENSIUOG00005034504
 protein coding gene Chr12:103886197-103929065 (+)



Homology
more
  • Human Ortholog
    COA8, cytochrome c oxidase assembly factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COA8, cytochrome c oxidase assembly factor 8
  • Synonyms
    APOP, APOP1, APOPT1, C14orf153, MC4DN17
  • Links
    NCBI Gene ID: 84334
    UniProt: Q96IL0

  • Chr Location
    14q32.33; chr14:103562960-103607523 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COA8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO leads to defects in the mitochondrial respiratory chain, resulting in impaired endurance, coordination and locomotor activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    34
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037787 Ensembl Gene Model | MGI Sequence Detail 41793 C57BL/6J ±  kb
transcript ENSMUST00000163220 Ensembl | MGI Sequence Detail 671 Not Applicable  
polypeptide ENSMUSP00000131169 Ensembl | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920751, MGI:6391256
References
more
  • Summaries
    All 38
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory