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Med8 Gene Detail
Summary
  • Symbol
    Med8
  • Name
    mediator complex subunit 8
  • Synonyms
    2210021A15Rik, ARC32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915269
    NCBI Gene: 80509
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118266534-118272979 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.61 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915269
 protein coding gene Chr4:118266495-118273021 (+)
129S1/SvImJ ENSMUSG00200013306
 protein coding gene Chr4:112165286-112171722 (+)
A/J ENSMUSG00195028049
 protein coding gene Chr4:113417435-113423844 (+)
AKR/J ENSMUSG00220018981
 protein coding gene Chr4:112764726-112771171 (+)
BALB/cJ ENSMUSG00180041697
 protein coding gene Chr4:111484576-111490986 (+)
C3H/HeJ ENSMUSG00175023050
 protein coding gene Chr4:112498771-112505180 (+)
C57BL/6NJ ENSMUSG00215037289
 protein coding gene Chr4:113591523-113597968 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026373
 protein coding gene Chr4:108851005-108857393 (+)
CAST/EiJ ENSTCUG00005045348
 protein coding gene Chr4:112272014-112278460 (+)
CBA/J ENSMUSG00210051982
 protein coding gene Chr4:112112445-112118854 (+)
DBA/2J ENSMUSG00185039999
 protein coding gene Chr4:113642946-113649354 (+)
FVB/NJ ENSMUSG00205024925
 protein coding gene Chr4:111581912-111588322 (+)
JF1/MsJ ENSUMUG00000004812
 protein coding gene Chr4:113559673-113566115 (+)
LP/J ENSMUSG00230043566
 protein coding gene Chr4:116980839-116987275 (+)
NOD/ShiLtJ ENSMUSG00190043068
 protein coding gene Chr4:111480238-111486647 (+)
NZO/HlLtJ ENSMUSG00225009907
 protein coding gene Chr4:122463426-122469867 (+)
PWK/PhJ ENSLUMG00010046610
 protein coding gene Chr4:110942898-110949304 (+)
SPRET/EiJ ENSMSPG00010037245
 protein coding gene Chr4:113031369-113037824 (+)
WSB/EiJ ENSIUOG00005044776
 protein coding gene Chr4:111798153-111804561 (+)



Homology
more
  • Human Ortholog
    MED8, mediator complex subunit 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED8, mediator complex subunit 8
  • Synonyms
    ARC32
  • Links
    NCBI Gene ID: 112950
    UniProt: Q96G25

  • Chr Location
    1p34.2; chr1:43383917-43389808 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Med8
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    15
  • cDNA Data
    76
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006392 Ensembl Gene Model | MGI Sequence Detail 6446 C57BL/6J ±  kb
transcript ENSMUST00000019229 Ensembl | MGI Sequence Detail 1145 Not Applicable  
polypeptide ENSMUSP00000019229 Ensembl | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 76
    Primer pair 2
    Antibodies 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:1930919
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:379748 Zhu S, et al., The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 2024 Nov 1;356:123020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory