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Saraf Gene Detail
Summary
  • Symbol
    Saraf
  • Name
    store-operated calcium entry-associated regulatory factor
  • Synonyms
    1810045K07Rik, Tmem66
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915137
    NCBI Gene: 67887
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34621733-34638001 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.90 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915137
 protein coding gene Chr8:34621717-34638001 (+)
129S1/SvImJ ENSMUSG00200021700
 protein coding gene Chr8:29685046-29701076 (+)
A/J ENSMUSG00195005385
 protein coding gene Chr8:30201023-30217055 (+)
AKR/J ENSMUSG00220025177
 protein coding gene Chr8:29963783-29979816 (+)
BALB/cJ ENSMUSG00180005420
 protein coding gene Chr8:29744426-29760460 (+)
C3H/HeJ ENSMUSG00175006326
 protein coding gene Chr8:29907129-29923161 (+)
C57BL/6NJ ENSMUSG00215010920
 protein coding gene Chr8:29688882-29706762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030974
 protein coding gene Chr8:28366125-28381701 (+)
CAST/EiJ ENSTCUG00005021161
 protein coding gene Chr8:29874146-29890295 (+)
CBA/J ENSMUSG00210013408
 protein coding gene Chr8:29730107-29746138 (+)
DBA/2J ENSMUSG00185002001
 protein coding gene Chr8:35656367-35672399 (+)
FVB/NJ ENSMUSG00205003364
 protein coding gene Chr8:28954865-28972741 (+)
JF1/MsJ ENSUMUG00000007778
 protein coding gene Chr8:37364242-37382119 (+)
LP/J ENSMUSG00230015274
 protein coding gene Chr8:39291208-39308684 (+)
NOD/ShiLtJ ENSMUSG00190004133
 protein coding gene Chr8:29772136-29795181 (+)
NZO/HlLtJ ENSMUSG00225014311
 protein coding gene Chr8:42901637-42919515 (+)
PWK/PhJ ENSLUMG00010025594
 protein coding gene Chr8:29602396-29618583 (+)
SPRET/EiJ ENSMSPG00010004224
 protein coding gene Chr8:30284386-30300429 (+)
WSB/EiJ ENSIUOG00005005297
 protein coding gene Chr8:30533612-30549590 (+)



Homology
more
  • Human Ortholog
    SARAF, store-operated calcium entry associated regulatory factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SARAF, store-operated calcium entry associated regulatory factor
  • Synonyms
    FOAP-7, HSPC035, TMEM66, XTP3
  • Links
    NCBI Gene ID: 51669
    UniProt: Q96BY9

  • Chr Location
    8p12; chr8:30063003-30083208 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    14
  • cDNA Data
    230
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67887 NCBI Gene Model | MGI Sequence Detail 16269 C57BL/6J ±  kb
    transcript NM_026432 RefSeq | MGI Sequence Detail 1883 C57BL/6  
    polypeptide Q8R3Q0 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029746 store-operated calcium entry-associated regulatory factor
      (term hierarchy)
    • InterPro Domains
      IPR009567 Store-operated calcium entry-associated regulatory factor
    • GlyGen
      Q8R3Q0 1 site
    Molecular
    Reagents
    less
    • All nucleic 230
      cDNA 230

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:369747 Lin S, et al., Rbpms2 prevents major cardiac defects in cardiomyocyte-specific Rbpms-deficient mice. Dev Cell. 2025 Jun 24;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory