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Mtln Gene Detail
Summary
  • Symbol
    Mtln
  • Name
    mitoregulin
  • Synonyms
    1500011K16Rik, Moxi
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915135
    NCBI Gene: 67885
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127633308-127634408 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915135
 protein coding gene Chr2:127633302-127634408 (-)
129S1/SvImJ ENSMUSG00200047300
 protein coding gene Chr2:124685894-124686995 (-)
A/J ENSMUSG00195029284
 protein coding gene Chr2:124713346-124714448 (-)
AKR/J ENSMUSG00220041191
 protein coding gene Chr2:124479685-124480786 (-)
BALB/cJ ENSMUSG00180044354
 protein coding gene Chr2:124502351-124503453 (-)
C3H/HeJ ENSMUSG00175045904
 protein coding gene Chr2:125044119-125045220 (-)
C57BL/6NJ ENSMUSG00215014177
 protein coding gene Chr2:124554695-124555795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024266
 protein coding gene Chr2:120618040-120619175 (-)
CAST/EiJ ENSTCUG00005034062
 protein coding gene Chr2:123839287-123840388 (-)
CBA/J ENSMUSG00210034376
 protein coding gene Chr2:124894542-124895643 (-)
DBA/2J ENSMUSG00185031285
 protein coding gene Chr2:124548676-124549777 (-)
FVB/NJ ENSMUSG00205025961
 protein coding gene Chr2:123734233-123735334 (-)
JF1/MsJ ENSUMUG00000007003
 protein coding gene Chr2:124399646-124400747 (-)
LP/J ENSMUSG00230033208
 protein coding gene Chr2:126321306-126322407 (-)
NOD/ShiLtJ ENSMUSG00190012536
 protein coding gene Chr2:124679132-124680233 (-)
NZO/HlLtJ ENSMUSG00225027347
 protein coding gene Chr2:134227491-134228592 (-)
PWK/PhJ ENSLUMG00010033968
 protein coding gene Chr2:124291285-124292386 (-)
SPRET/EiJ ENSMSPG00010029669
 protein coding gene Chr2:126727620-126727974 (-)
WSB/EiJ ENSIUOG00005039304
 protein coding gene Chr2:124489922-124491025 (-)



Homology
more
  • Human Ortholog
    MTLN, mitoregulin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTLN, mitoregulin
  • Synonyms
    LEMP, LINC00116, MOXI, MPM, NCRNA00116, SMIM37, TILR
  • Links
    NCBI Gene ID: 205251
    UniProt: Q8NCU8

  • Chr Location
    2q13; chr2:110211529-110245420 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mitrochondrial respiratory complex formation and calcium retention capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    11
  • cDNA Data
    25
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      37
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051319 Ensembl Gene Model | MGI Sequence Detail 1101 C57BL/6J ±  kb
    transcript ENSMUST00000135091 Ensembl | MGI Sequence Detail 800 Not Applicable  
    polypeptide ENSMUSP00000141107 Ensembl | MGI Sequence Detail 56 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR038778 Mitoregulin
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6191655
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353662 Chen HX, et al., Micropeptide MPM regulates cardiomyocyte proliferation and heart growth via the AKT pathway. Biochim Biophys Acta Mol Cell Res. 2024 Aug 18;1871(8):119820
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory