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Tex46 Gene Detail
Summary
  • Symbol
    Tex46
  • Name
    testis expressed 46
  • Synonyms
    4930549C01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914913
    NCBI Gene: 67663
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136337748-136340537 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.92 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914913
 protein coding gene Chr4:136334313-136340590 (+)
129S1/SvImJ ENSMUSG00200018476
 protein coding gene Chr4:129755470-129758262 (+)
A/J ENSMUSG00195039513
 protein coding gene Chr4:131104005-131107142 (+)
AKR/J ENSMUSG00220045440
 protein coding gene Chr4:130099413-130102515 (+)
BALB/cJ ENSMUSG00180048716
 protein coding gene Chr4:128737892-128741025 (+)
C3H/HeJ ENSMUSG00175042185
 protein coding gene Chr4:129758606-129761706 (+)
C57BL/6NJ ENSMUSG00215048741
 protein coding gene Chr4:131278237-131281028 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026665
 protein coding gene Chr4:126288178-126290975 (+)
CAST/EiJ ENSTCUG00005046568
 protein coding gene Chr4:130686460-130689272 (+)
CBA/J ENSMUSG00210053071
 protein coding gene Chr4:129382494-129385600 (+)
DBA/2J ENSMUSG00185051624
 protein coding gene Chr4:130911192-130914325 (+)
FVB/NJ ENSMUSG00205033110
 protein coding gene Chr4:129151719-129154852 (+)
JF1/MsJ ENSUMUG00000016557
 protein coding gene Chr4:131612018-131614809 (+)
LP/J ENSMUSG00230040038
 protein coding gene Chr4:134693651-134696442 (+)
NOD/ShiLtJ ENSMUSG00190035636
 protein coding gene Chr4:129143255-129146388 (+)
NZO/HlLtJ ENSMUSG00225026470
 protein coding gene Chr4:140648686-140651475 (+)
PWK/PhJ ENSLUMG00010044183
 protein coding gene Chr4:128593883-128597019 (+)
SPRET/EiJ ENSMSPG00010038241
 protein coding gene Chr4:130667237-130670074 (+)
WSB/EiJ ENSIUOG00005039026
 protein coding gene Chr4:129045819-129048759 (+)



Homology
more
  • Human Ortholog
    TEX46, testis expressed 46
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEX46, testis expressed 46
  • Synonyms
    C1orf234, TEX#
  • Links
    NCBI Gene ID: 729059
    UniProt: H3BTG2

  • Chr Location
    1p36.12; chr1:23010834-23019100 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are infertile with abnormal sperm head formation and sperm motility. Sperm lack the hook-shape head appearance and fail to penetrate the zona pellucida.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036921 Ensembl Gene Model | MGI Sequence Detail 2790 C57BL/6J ±  kb
    transcript ENSMUST00000046647 Ensembl | MGI Sequence Detail 683 Not Applicable  
    polypeptide ENSMUSP00000038976 Ensembl | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR038788 Testis-expressed protein 46-like
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:5882227
    References
    more
    • Summaries
      All 26
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:355678 Fujihara Y, et al., Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida. PNAS Nexus. 2024 Mar;3(3):pgae108
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory