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Tmem35a Gene Detail
Summary
  • Symbol
    Tmem35a
  • Name
    transmembrane protein 35A
  • Synonyms
    9030603L14Rik, NACHO, Tmem35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914814
    NCBI Gene: 67564
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:133195974-133206718 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914814
 protein coding gene ChrX:133195974-133206718 (+)
129S1/SvImJ ENSMUSG00200044529
 protein coding gene ChrX:112259850-112270628 (+)
A/J ENSMUSG00195045879
 protein coding gene ChrX:116121732-116132515 (+)
AKR/J ENSMUSG00220012815
 protein coding gene ChrX:109732885-109743670 (+)
BALB/cJ ENSMUSG00180033625
 protein coding gene ChrX:112539899-112550678 (+)
C3H/HeJ ENSMUSG00175030475
 protein coding gene ChrX:116388267-116399054 (+)
C57BL/6NJ ENSMUSG00215043184
 protein coding gene ChrX:112901889-112912633 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033388
 protein coding gene ChrX:123071996-123082695 (+)
CAST/EiJ ENSTCUG00005039592
 protein coding gene ChrX:113709811-113720592 (+)
CBA/J ENSMUSG00210035857
 protein coding gene ChrX:113289898-113300681 (+)
DBA/2J ENSMUSG00185029367
 protein coding gene ChrX:127214352-127225139 (+)
FVB/NJ ENSMUSG00205011998
 protein coding gene ChrX:111910397-111921142 (+)
JF1/MsJ ENSUMUG00000015315
 protein coding gene ChrX:146364604-146375383 (+)
LP/J ENSMUSG00230039084
 protein coding gene ChrX:133903035-133913818 (+)
NOD/ShiLtJ ENSMUSG00190028177
 protein coding gene ChrX:112718166-112728912 (+)
NZO/HlLtJ ENSMUSG00225036775
 protein coding gene ChrX:138556640-138567401 (+)
PWK/PhJ ENSLUMG00010008944
 protein coding gene ChrX:111033829-111044575 (+)
SPRET/EiJ ENSMSPG00010038006
 protein coding gene ChrX:115875036-115885525 (+)
WSB/EiJ ENSIUOG00005035275
 protein coding gene ChrX:113457706-113468486 (+)



Homology
more
  • Human Ortholog
    TMEM35A, transmembrane protein 35A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM35A, transmembrane protein 35A
  • Synonyms
    NACHO, TMEM35, TUF-1, TUF1
  • Links
    NCBI Gene ID: 59353
    UniProt: Q53FP2

  • Chr Location
    Xq22.1; chrX:101078879-101096367 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout causes a reduction in hippocampal long-term potentiation, which results in impairment of fear learning and long-term spatial reference memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    38
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67564 NCBI Gene Model | MGI Sequence Detail 10745 C57BL/6J ±  kb
    transcript NM_026239 RefSeq | MGI Sequence Detail 1979 Not Specified  
    polypeptide Q9D328 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147917
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory