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Mmd Gene Detail
Summary
  • Symbol
    Mmd
  • Name
    monocyte to macrophage differentiation-associated
  • Synonyms
    1200017E07Rik, 1810073C06Rik, Paqr11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914718
    NCBI Gene: 67468
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:90140282-90169415 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 54.89 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1088 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914718
 protein coding gene Chr11:90078513-90169415 (+)
129S1/SvImJ ENSMUSG00200020170
 protein coding gene Chr11:87251274-87300571 (+)
A/J ENSMUSG00195007643
 protein coding gene Chr11:87106408-87135452 (+)
AKR/J ENSMUSG00220010541
 protein coding gene Chr11:87306222-87335264 (+)
BALB/cJ ENSMUSG00180011060
 protein coding gene Chr11:87330174-87359307 (+)
C3H/HeJ ENSMUSG00175027262
 protein coding gene Chr11:87252707-87281749 (+)
C57BL/6NJ ENSMUSG00215015678
 protein coding gene Chr11:86950869-86980006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016961
 protein coding gene Chr11:85438154-85528449 (+)
CAST/EiJ ENSTCUG00005016063
 protein coding gene Chr11:86830864-86860059 (+)
CBA/J ENSMUSG00210037605
 protein coding gene Chr11:87070265-87099309 (+)
DBA/2J ENSMUSG00185019375
 protein coding gene Chr11:87386520-87415562 (+)
FVB/NJ ENSMUSG00205011729
 protein coding gene Chr11:87280065-87309362 (+)
JF1/MsJ ENSUMUG00000013329
 protein coding gene Chr11:87752108-87781360 (+)
LP/J ENSMUSG00230025544
 protein coding gene Chr11:88420003-88449049 (+)
NOD/ShiLtJ ENSMUSG00190017964
 protein coding gene Chr11:87432367-87461411 (+)
NZO/HlLtJ ENSMUSG00225038310
 protein coding gene Chr11:90547547-90576692 (+)
PWK/PhJ ENSLUMG00010028205
 protein coding gene Chr11:87278077-87307331 (+)
SPRET/EiJ ENSMSPG00010024196
 protein coding gene Chr11:87679410-87708156 (+)
WSB/EiJ ENSIUOG00005007072
 protein coding gene Chr11:87239632-87268826 (+)



Homology
more
  • Human Ortholog
    MMD, monocyte to macrophage differentiation associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMD, monocyte to macrophage differentiation associated
  • Synonyms
    MMA, MMD1, PAQR11
  • Links
    NCBI Gene ID: 23531
    UniProt: Q15546

  • Chr Location
    17q22; chr17:55392616-55421944 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired macrophage differentiation, increased macrophage apoptosis, and decreased susceptibility to induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    54
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003948 Ensembl Gene Model | MGI Sequence Detail 29134 C57BL/6J ±  kb
    transcript ENSMUST00000004050 Ensembl | MGI Sequence Detail 2677 Not Applicable  
    polypeptide ENSMUSP00000004050 Ensembl | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917116, MGI:2144046
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory