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Hoga1 Gene Detail
Summary
  • Symbol
    Hoga1
  • Name
    4-hydroxy-2-oxoglutarate aldolase 1
  • Synonyms
    0610010D20Rik, Dhdpsl, Npl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914682
    NCBI Gene: 67432
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42034049-42059392 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 35.67 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914682
 protein coding gene Chr19:42033998-42060128 (+)
129S1/SvImJ ENSMUSG00200026299
 protein coding gene Chr19:38768792-38796567 (+)
A/J ENSMUSG00195010573
 protein coding gene Chr19:38873504-38901274 (+)
AKR/J ENSMUSG00220018536
 protein coding gene Chr19:38685586-38713361 (+)
BALB/cJ ENSMUSG00180029050
 protein coding gene Chr19:39125916-39153688 (+)
C3H/HeJ ENSMUSG00175036685
 protein coding gene Chr19:38647776-38675551 (+)
C57BL/6NJ ENSMUSG00215024707
 protein coding gene Chr19:38723506-38751456 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022964
 protein coding gene Chr19:38722407-38750840 (+)
CAST/EiJ ENSTCUG00005013917
 protein coding gene Chr19:38331482-38358595 (+)
CBA/J ENSMUSG00210032109
 protein coding gene Chr19:38729900-38757675 (+)
DBA/2J ENSMUSG00185032906
 protein coding gene Chr19:39250083-39277858 (+)
FVB/NJ ENSMUSG00205006570
 protein coding gene Chr19:38200621-38228388 (+)
JF1/MsJ ENSUMUG00000032226
 protein coding gene Chr19:39413999-39438892 (+)
LP/J ENSMUSG00230034336
 protein coding gene Chr19:40038879-40066654 (+)
NOD/ShiLtJ ENSMUSG00190011111
 protein coding gene Chr19:38599895-38627670 (+)
NZO/HlLtJ ENSMUSG00225041820
 protein coding gene Chr19:43597128-43624894 (+)
PWK/PhJ ENSLUMG00010000857
 protein coding gene Chr19:38583101-38608030 (+)
SPRET/EiJ ENSMSPG00010019653
 protein coding gene Chr19:38315933-38340882 (+)
WSB/EiJ ENSIUOG00005036757
 protein coding gene Chr19:38106546-38134544 (+)



Homology
more
  • Human Ortholog
    HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1
  • Synonyms
    C10orf65, DHDPS2, DHDPSL, HP3, NPL2
  • Links
    NCBI Gene ID: 112817
    UniProt: Q86XE5

  • Chr Location
    10q24.2; chr10:97584323-97612802 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hoga1 mouse models; 1 with human HOGA1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal urinary excretion of oxalate but show increased urine 2,4-dihydroxyglutarate (DHG) levels especially when challenged by the inclusion of hydroxyproline in the diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025176 Ensembl Gene Model | MGI Sequence Detail 25344 C57BL/6J ±  kb
    transcript ENSMUST00000081714 Ensembl | MGI Sequence Detail 1668 Not Applicable  
    polypeptide ENSMUSP00000080414 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Diseases 1
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:364605 Wang C, et al., HOGA1 Suppresses Renal Cell Carcinoma Growth via Inhibiting the Wnt/beta-Catenin Signalling Pathway. J Cell Mol Med. 2025 Mar;29(6):e70490
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory