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Kctd16 Gene Detail
Summary
  • Symbol
    Kctd16
  • Name
    potassium channel tetramerisation domain containing 16
  • Synonyms
    2900055J20Rik, 4930434H12Rik, LOC383347
Location &
Maps
more
  • Sequence Map
    Chr18:40389358-40680311 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7072 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914659
 protein coding gene Chr18:40389358-40680311 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024372
 protein coding gene Chr18:38823991-39124802 (+)
A/J MGP_AJ_G0024339
 protein coding gene Chr18:37479446-37763088 (+)
AKR/J MGP_AKRJ_G0024308
 protein coding gene Chr18:38477439-38766632 (+)
BALB/cJ MGP_BALBcJ_G0024339
 protein coding gene Chr18:37526964-37815767 (+)
C3H/HeJ MGP_C3HHeJ_G0024105
 protein coding gene Chr18:38561706-38855451 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024781
 protein coding gene Chr18:40161121-40454417 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022220
 protein coding gene Chr18:37434779-37701563 (+)
CAST/EiJ MGP_CASTEiJ_G0023580
 protein coding gene Chr18:38526440-38814549 (+)
CBA/J MGP_CBAJ_G0024075
 protein coding gene Chr18:41377031-41699478 (+)
DBA/2J MGP_DBA2J_G0024205
 protein coding gene Chr18:37058802-37335531 (+)
FVB/NJ MGP_FVBNJ_G0024171
 protein coding gene Chr18:36769056-37035278 (+)
LP/J MGP_LPJ_G0024289
 protein coding gene Chr18:38868020-39156397 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024202
 protein coding gene Chr18:42539430-42841072 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024830
 protein coding gene Chr18:38375480-38673563 (+)
PWK/PhJ MGP_PWKPhJ_G0023324
 protein coding gene Chr18:37301034-37577934 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023129
 protein coding gene Chr18:38615726-38891573 (+)
WSB/EiJ MGP_WSBEiJ_G0023643
 protein coding gene Chr18:38261646-38552548 (+)



Homology
more
  • Human Ortholog
    KCTD16, potassium channel tetramerization domain containing 16
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCTD16, potassium channel tetramerization domain containing 16
  • Links
    NCBI Gene ID: 57528
    UniProt: Q68DU8

  • Chr Location
    5q31.3; chr5:144170873-144485686 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1546
  • Tissues
    17
  • cDNA Data
    18
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 383348 NCBI Gene Model | MGI Sequence Detail 290954 C57BL/6J ±  kb
transcript NM_001371039 RefSeq | MGI Sequence Detail 18419 C57BL/6  
polypeptide Q5DTY9 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031813 BTB/POZ domain-containing protein KCTD16
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR049903 Potassium channel tetramerization domain-containing protein 16, H1 domain
    IPR011333 SKP1/BTB/POZ domain superfamily
  • GlyGen
    Q5DTY9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 4
Other
Accession IDs
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MGI:1920251, MGI:1924774, MGI:2686113
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:371858 Perez-Garci E, et al., Binding of HCN channels to GABA(B) receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety. Neurobiol Dis. 2025 Mar;206:106831
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory