Dram2 MGI Mouse Gene Detail - MGI:1914421 - DNA-damage regulated autophagy modulator 2

Symbol

Dram2
Name

DNA-damage regulated autophagy modulator 2
Synonyms

2010305N14Rik, 2610318G18Rik, Tmem77

Feature Type

protein coding gene
IDs

MGI:1914421
NCBI Gene: 67171
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:106455114-106482657 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.50 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

581 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914421	protein coding gene	Chr3:106455114-106483206 (+)
129S1/SvImJ	ENSMUSG00200034011	protein coding gene	Chr3:103055497-103083604 (+)
A/J	ENSMUSG00195024299	protein coding gene	Chr3:103488166-103516249 (+)
AKR/J	ENSMUSG00220030972	protein coding gene	Chr3:101853314-101881405 (+)
BALB/cJ	ENSMUSG00180018599	protein coding gene	Chr3:103440404-103468479 (+)
C3H/HeJ	ENSMUSG00175028081	protein coding gene	Chr3:102968401-102996478 (+)
C57BL/6NJ	ENSMUSG00215014140	protein coding gene	Chr3:103704661-103732755 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025489	protein coding gene	Chr3:100765157-100793552 (+)
CAST/EiJ	ENSTCUG00005026051	protein coding gene	Chr3:103965136-103993205 (+)
CBA/J	ENSMUSG00210007463	protein coding gene	Chr3:103590365-103618438 (+)
DBA/2J	ENSMUSG00185021106	protein coding gene	Chr3:104061539-104089635 (+)
FVB/NJ	ENSMUSG00205019612	protein coding gene	Chr3:102631831-102659923 (+)
JF1/MsJ	ENSUMUG00000002930	protein coding gene	Chr3:103032173-103060284 (+)
LP/J	ENSMUSG00230014125	protein coding gene	Chr3:105982951-106011044 (+)
NOD/ShiLtJ	ENSMUSG00190033337	protein coding gene	Chr3:104299079-104327154 (+)
NZO/HlLtJ	ENSMUSG00225016252	protein coding gene	Chr3:108469987-108498057 (+)
PWK/PhJ	ENSLUMG00010023385	protein coding gene	Chr3:102878864-102906946 (+)
SPRET/EiJ	ENSMSPG00010027695	protein coding gene	Chr3:103328401-103360224 (+)
WSB/EiJ	ENSIUOG00005004365	protein coding gene	Chr3:103605998-103634099 (+)

Human Ortholog

DRAM2, DNA damage regulated autophagy modulator 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRAM2, DNA damage regulated autophagy modulator 2
Synonyms

CORD21, PRO180, TMEM77, WWFQ154
Links

HGNC:28769

NCBI Gene ID: 128338

UniProt: Q6UX65
Chr Location

1p13.3; chr1:111115884-111140225 (-) GRCh38

MGI Vertebrate Homology

Dram2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DRAM2
Gene Tree

Dram2

Diseases

1 with Dram2 mouse models; 1 with human DRAM2 associations

Human Disease

Mouse Models

cone-rod dystrophy 21

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

19
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Dram2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show age-related photoreceptor degeneration starting at 18 months of age without impacting visual function.

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All GO Annotations

27
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

673
Tissues

38
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dram2b

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All Sequences

75
RefSeq

20
UniProt

7
CCDS

CCDS17724.1, CCDS17725.1

Ensembl

ENSMUSG00000027900 (Evidence)
NCBI Gene

67171

			Length	Strain/Species	Flank
genomic	67171	NCBI Gene Model \| MGI Sequence Detail	27544	C57BL/6J	± kb
transcript	NR_190545	RefSeq \| MGI Sequence Detail	2354	C57BL/6
polypeptide	Q9CR48	UniProt \| EBI \| MGI Sequence Detail	267	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000029432 DNA damage-regulated autophagy modulator protein 2

(term hierarchy)
InterPro Domains

IPR019402 CWH43-like, N-terminal domain

IPR050911 DRAM/TMEM150 Autophagy Modulator

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:1919359, MGI:2139771

Summaries

All 50

Developmental Gene Expression 3

Diseases 2

Gene Ontology 7

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dram2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31114	Chr3:106453196-106453215 (+)	-1,908 bp
Tssr31115	Chr3:106455013-106455030 (+)	-92 bp
Tssr31116	Chr3:106455043-106455054 (+)	-65 bp
Tssr31117	Chr3:106455138-106455204 (+)	57 bp
Tssr31118	Chr3:106469483-106469492 (+)	14,374 bp
Tssr31125	Chr3:106481041-106481053 (+)	25,933 bp
Tssr31126	Chr3:106481099-106481111 (+)	25,991 bp
Tssr31127	Chr3:106481214-106481225 (+)	26,106 bp
Tssr31128	Chr3:106481288-106481305 (+)	26,183 bp
Tssr31129	Chr3:106481344-106481356 (+)	26,236 bp
Tssr31130	Chr3:106481358-106481385 (+)	26,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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