About   Help   FAQ
Naaa Gene Detail
Summary
  • Symbol
    Naaa
  • Name
    N-acylethanolamine acid amidase
  • Synonyms
    2210023K21Rik, 3830414F09Rik, Asahl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914361
    NCBI Gene: 67111
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92405518-92426029 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.35 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    764 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914361
 protein coding gene Chr5:92405518-92426040 (-)
129S1/SvImJ ENSMUSG00200007335
 protein coding gene Chr5:88156391-88176718 (-)
A/J ENSMUSG00195025488
 protein coding gene Chr5:87308556-87329069 (-)
AKR/J ENSMUSG00220011537
 protein coding gene Chr5:87459083-87479399 (-)
BALB/cJ ENSMUSG00180024848
 protein coding gene Chr5:87153499-87173815 (-)
C3H/HeJ ENSMUSG00175036937
 protein coding gene Chr5:89254262-89274580 (-)
C57BL/6NJ ENSMUSG00215016272
 protein coding gene Chr5:88005803-88026318 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027412
 protein coding gene Chr5:85371231-85392148 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210006079
 protein coding gene Chr5:88032988-88053304 (-)
DBA/2J ENSMUSG00185038362
 protein coding gene Chr5:89969739-89990056 (-)
FVB/NJ ENSMUSG00205019737
 protein coding gene Chr5:86858433-86878750 (-)
JF1/MsJ ENSUMUG00000025197
 protein coding gene Chr5:94220080-94241142 (-)
LP/J ENSMUSG00230024177
 protein coding gene Chr5:94667604-94687933 (-)
NOD/ShiLtJ ENSMUSG00190036905
 protein coding gene Chr5:86937143-86957654 (-)
NZO/HlLtJ ENSMUSG00225008550
 protein coding gene Chr5:99808416-99828927 (-)
PWK/PhJ ENSLUMG00010027496
 protein coding gene Chr5:86898669-86919569 (-)
SPRET/EiJ ENSMSPG00010032467
 protein coding gene Chr5:89270862-89289460 (-)
WSB/EiJ ENSIUOG00005026340
 protein coding gene Chr5:89931814-89952189 (-)



Homology
more
  • Human Ortholog
    NAAA, N-acylethanolamine acid amidase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAAA, N-acylethanolamine acid amidase
  • Synonyms
    ASAHL, PLT
  • Links
    NCBI Gene ID: 27163
    UniProt: Q02083

  • Chr Location
    4q21.1; chr4:75910655-75941013 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop significantly less ear edema and scratching behavior in a model of DNFB-induced allergic contact dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    6
  • cDNA Data
    37
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029413 Ensembl Gene Model | MGI Sequence Detail 20512 C57BL/6J ±  kb
    transcript ENSMUST00000113102 Ensembl | MGI Sequence Detail 2414 Not Applicable  
    polypeptide ENSMUSP00000108726 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917957
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:371490 Izumi Y, et al., Generation of Astrocyte-Selective Cre Driver Lines With Distinct Onsets of Recombination Activity During Development. Genesis. 2025 Oct;63(5):e70025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory