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Rars1 Gene Detail
Summary
  • Symbol
    Rars1
  • Name
    arginyl-tRNA synthetase 1
  • Synonyms
    2610011N19Rik, 2610037E21Rik, Rars
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914297
    NCBI Gene: 104458
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:35699208-35725333 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    952 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914297
 protein coding gene Chr11:35699207-35725355 (-)
129S1/SvImJ ENSMUSG00200006831
 protein coding gene Chr11:32753828-32779953 (-)
A/J ENSMUSG00195006956
 protein coding gene Chr11:32678831-32704979 (-)
AKR/J ENSMUSG00220003132
 protein coding gene Chr11:32864484-32890634 (-)
BALB/cJ ENSMUSG00180001660
 protein coding gene Chr11:32678961-32705109 (-)
C3H/HeJ ENSMUSG00175003585
 protein coding gene Chr11:32648663-32674806 (-)
C57BL/6NJ ENSMUSG00215009712
 protein coding gene Chr11:32602897-32629022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016208
 protein coding gene Chr11:31387269-31416776 (-)
CAST/EiJ ENSTCUG00005012974
 protein coding gene Chr11:32509394-32536037 (-)
CBA/J ENSMUSG00210006590
 protein coding gene Chr11:32534887-32561037 (-)
DBA/2J ENSMUSG00185010004
 protein coding gene Chr11:32727992-32754135 (-)
FVB/NJ ENSMUSG00205011202
 protein coding gene Chr11:32774399-32800524 (-)
JF1/MsJ ENSUMUG00000004823
 protein coding gene Chr11:33045614-33072286 (-)
LP/J ENSMUSG00230003040
 protein coding gene Chr11:33899070-33925218 (-)
NOD/ShiLtJ ENSMUSG00190007217
 protein coding gene Chr11:32795456-32822126 (-)
NZO/HlLtJ ENSMUSG00225030390
 protein coding gene Chr11:35838019-35865270 (-)
PWK/PhJ ENSLUMG00010007169
 protein coding gene Chr11:32616454-32642990 (-)
SPRET/EiJ ENSMSPG00010002231
 protein coding gene Chr11:32995660-33022290 (-)
WSB/EiJ ENSIUOG00005002020
 protein coding gene Chr11:32701575-32727692 (-)



Homology
more
  • Human Ortholog
    RARS1, arginyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RARS1, arginyl-tRNA synthetase 1
  • Synonyms
    ArgRS, DALRD1, HLD9, RARS
  • Links
    NCBI Gene ID: 5917
    UniProt: P54136

  • Chr Location
    5q34; chr5:168486447-168519306 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RARS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    95
  • cDNA Data
    249
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018848 Ensembl Gene Model | MGI Sequence Detail 26126 C57BL/6J ±  kb
transcript ENSMUST00000018992 Ensembl | MGI Sequence Detail 2109 Not Applicable  
polypeptide ENSMUSP00000018992 Ensembl | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013742 arginine--tRNA ligase, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.19
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR001278 Arginine-tRNA ligase
    IPR035684 Arginyl-tRNA synthetase, catalytic core domain
    IPR005148 Arginyl tRNA synthetase N-terminal domain
    IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
    IPR008909 DALR anticodon binding
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
  • GlyGen
    Q9D0I9 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 251
    cDNA 249
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924077, MGI:2144362, MGI:2144591, MGI:7482291
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory