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Trim35 Gene Detail
Summary
  • Symbol
    Trim35
  • Name
    tripartite motif-containing 35
  • Synonyms
    0710005M05Rik, A430106H13Rik, Hls5, Mair, mKIAA1098
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914104
    NCBI Gene: 66854
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66534480-66548873 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.44 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914104
 protein coding gene Chr14:66534474-66548873 (+)
129S1/SvImJ ENSMUSG00200029833
 protein coding gene Chr14:55142364-55156754 (+)
A/J ENSMUSG00195013492
 protein coding gene Chr14:55312548-55326950 (+)
AKR/J ENSMUSG00220027030
 protein coding gene Chr14:54653089-54667497 (+)
BALB/cJ ENSMUSG00180030066
 protein coding gene Chr14:54928778-54943182 (+)
C3H/HeJ ENSMUSG00175031325
 protein coding gene Chr14:56678770-56693161 (+)
C57BL/6NJ ENSMUSG00215015865
 protein coding gene Chr14:54867741-54882136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019438
 protein coding gene Chr14:57454394-57469413 (+)
CAST/EiJ ENSTCUG00005034303
 protein coding gene Chr14:56574244-56588680 (+)
CBA/J ENSMUSG00210032463
 protein coding gene Chr14:55299901-55314304 (+)
DBA/2J ENSMUSG00185031871
 protein coding gene Chr14:60476612-60491003 (+)
FVB/NJ ENSMUSG00205028698
 protein coding gene Chr14:54815403-54829809 (+)
JF1/MsJ ENSUMUG00000024816
 protein coding gene Chr14:71645430-71659764 (+)
LP/J ENSMUSG00230036734
 protein coding gene Chr14:72505869-72520260 (+)
NOD/ShiLtJ ENSMUSG00190036999
 protein coding gene Chr14:55094589-55108992 (+)
NZO/HlLtJ ENSMUSG00225039209
 protein coding gene Chr14:62827468-62841869 (+)
PWK/PhJ ENSLUMG00010030404
 protein coding gene Chr14:54535961-54550307 (+)
SPRET/EiJ ENSMSPG00010029094
 protein coding gene Chr14:58023373-58037720 (+)
WSB/EiJ ENSIUOG00005035630
 protein coding gene Chr14:54533067-54547478 (+)



Homology
more
  • Human Ortholog
    TRIM35, tripartite motif containing 35
  • Vertebrate Orthologs
    19
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM35, tripartite motif containing 35
  • Synonyms
    HLS5, MAIR
  • Links
    NCBI Gene ID: 23087
    UniProt: Q9UPQ4

  • Chr Location
    8p21.2; chr8:27284886-27311289 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased serum interferon-beta levels in response to vesicular stomatitis virus infection and show increased susceptibility to influenza A virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    77
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022043 Ensembl Gene Model | MGI Sequence Detail 14394 C57BL/6J ±  kb
    transcript ENSMUST00000022623 Ensembl | MGI Sequence Detail 3678 Not Applicable  
    polypeptide ENSMUSP00000022623 Ensembl | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925036, MGI:2145786
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory