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Nacc1 Gene Detail
Summary
  • Symbol
    Nacc1
  • Name
    nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
  • Synonyms
    2010001H03Rik, 4930511N13Rik, Btbd14b, Nac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914080
    NCBI Gene: 66830
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85397106-85414528 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914080
 protein coding gene Chr8:85397106-85414531 (-)
129S1/SvImJ ENSMUSG00200023579
 protein coding gene Chr8:79762097-79768811 (-)
A/J ENSMUSG00195014161
 protein coding gene Chr8:80120118-80126841 (-)
AKR/J ENSMUSG00220021502
 protein coding gene Chr8:80161632-80168359 (-)
BALB/cJ ENSMUSG00180018715
 protein coding gene Chr8:79960776-79967494 (-)
C3H/HeJ ENSMUSG00175010586
 protein coding gene Chr8:80055815-80062542 (-)
C57BL/6NJ ENSMUSG00215007954
 protein coding gene Chr8:79693263-79700041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031303
 protein coding gene Chr8:76005427-76022849 (-)
CAST/EiJ ENSTCUG00005032843
 protein coding gene Chr8:79570365-79577078 (-)
CBA/J ENSMUSG00210019932
 protein coding gene Chr8:80042942-80049665 (-)
DBA/2J ENSMUSG00185036244
 protein coding gene Chr8:86151526-86158253 (-)
FVB/NJ ENSMUSG00205017588
 protein coding gene Chr8:79098762-79105480 (-)
JF1/MsJ ENSUMUG00000013821
 protein coding gene Chr8:88459828-88466605 (-)
LP/J ENSMUSG00230028290
 protein coding gene Chr8:89759112-89765822 (-)
NOD/ShiLtJ ENSMUSG00190025311
 protein coding gene Chr8:80117077-80123791 (-)
NZO/HlLtJ ENSMUSG00225038910
 protein coding gene Chr8:93153974-93160751 (-)
PWK/PhJ ENSLUMG00010027262
 protein coding gene Chr8:79797406-79804173 (-)
SPRET/EiJ ENSMSPG00010023924
 protein coding gene Chr8:81712905-81719664 (-)
WSB/EiJ ENSIUOG00005015474
 protein coding gene Chr8:80857402-80864127 (-)



Homology
more
  • Human Ortholog
    NACC1, nucleus accumbens associated 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NACC1, nucleus accumbens associated 1
  • Synonyms
    BEND8, BTBD14B, BTBD30, NAC-1, NAC1, NECFM
  • Links
    NCBI Gene ID: 112939
    UniProt: Q96RE7

  • Chr Location
    19p13.13; chr19:13116468-13141147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 4 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased sensitivity to cocaine and amphetamine. Mice homozygous for a different knock-out allele exhibit thoracic vertebral transformation and loss of the sixth lumbar vertebrae with decreaed rib number and reduced chondrocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    14
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66830 NCBI Gene Model | MGI Sequence Detail 17423 C57BL/6J ±  kb
    transcript NM_025788 RefSeq | MGI Sequence Detail 4332 ZRU/MplStud  
    polypeptide Q7TSZ8 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 1
      Other 1
      Antibodies 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917610
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:354196 Deehan MA, et al., Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. J Neurosci. 2024 Apr 3;44(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory