About   Help   FAQ
Nkapl Gene Detail
Summary
  • Symbol
    Nkapl
  • Name
    NFKB activating protein-like
  • Synonyms
    4921504I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913957
    NCBI Gene: 66707
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:21651217-21652671 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 7.81 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913957
 protein coding gene Chr13:21651217-21652679 (-)
129S1/SvImJ ENSMUSG00200012055
 protein coding gene Chr13:18850148-18851610 (-)
A/J ENSMUSG00195037604
 protein coding gene Chr13:17994690-17996152 (-)
AKR/J ENSMUSG00220030210
 protein coding gene Chr13:17910042-17911504 (-)
BALB/cJ ENSMUSG00180031900
 protein coding gene Chr13:18355973-18357435 (-)
C3H/HeJ ENSMUSG00175032127
 protein coding gene Chr13:18461108-18462570 (-)
C57BL/6NJ ENSMUSG00215017458
 protein coding gene Chr13:18407186-18408648 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018272
 protein coding gene Chr13:16668494-16669958 (-)
CAST/EiJ ENSTCUG00005013740
 protein coding gene Chr13:18483323-18484791 (-)
CBA/J ENSMUSG00210028715
 protein coding gene Chr13:18322668-18324130 (-)
DBA/2J ENSMUSG00185013616
 protein coding gene Chr13:19017033-19018495 (-)
FVB/NJ ENSMUSG00205051371
 protein coding gene Chr13:18166490-18167952 (-)
JF1/MsJ ENSUMUG00000016551
 protein coding gene Chr13:18733408-18734867 (-)
LP/J ENSMUSG00230032340
 protein coding gene Chr13:28411081-28412543 (-)
NOD/ShiLtJ ENSMUSG00190019499
 protein coding gene Chr13:18275851-18277313 (-)
NZO/HlLtJ ENSMUSG00225045194
 protein coding gene Chr13:22171358-22172820 (-)
PWK/PhJ ENSLUMG00010029799
 protein coding gene Chr13:17726962-17728424 (-)
SPRET/EiJ ENSMSPG00010016945
 protein coding gene Chr13:17446307-17447775 (-)
WSB/EiJ ENSIUOG00005031081
 protein coding gene Chr13:17651811-17653273 (-)



Homology
more
  • Human Ortholog
    NKAPL, NFKB activating protein like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKAPL, NFKB activating protein like
  • Synonyms
    bA424I5.1, C6orf194
  • Links
    NCBI Gene ID: 222698
    UniProt: Q5M9Q1

  • Chr Location
    6p22.1; chr6:28259297-28260958 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with arrested male meiosis, male germ cell apoptosis and azzospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66707 NCBI Gene Model | MGI Sequence Detail 1455 C57BL/6J ±  kb
    transcript NM_025719 RefSeq | MGI Sequence Detail 1455 C57BL/6  
    polypeptide Q5SZT7 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR040466 NF-kappa-B-activating protein
      IPR009269 NF-kappa-B-activating protein, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 15
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:363051 Kang Z, et al., NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit. Nat Commun. 2025 Jan 17;16(1):791
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory