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Tmem268 Gene Detail
Summary
  • Symbol
    Tmem268
  • Name
    transmembrane protein 268
  • Synonyms
    6330416G13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913920
    NCBI Gene: 230279
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63477018-63504594 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    856 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913920
 protein coding gene Chr4:63472410-63504594 (+)
129S1/SvImJ ENSMUSG00200003062
 protein coding gene Chr4:58451441-58479017 (+)
A/J ENSMUSG00195008161
 protein coding gene Chr4:59033818-59061393 (+)
AKR/J ENSMUSG00220004962
 protein coding gene Chr4:58843342-58871009 (+)
BALB/cJ ENSMUSG00180027381
 protein coding gene Chr4:58019662-58047245 (+)
C3H/HeJ ENSMUSG00175021764
 protein coding gene Chr4:58802417-58829991 (+)
C57BL/6NJ ENSMUSG00215014689
 protein coding gene Chr4:58873661-58901239 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026094
 protein coding gene Chr4:57680326-57704030 (+)
CAST/EiJ ENSTCUG00005007752
 protein coding gene Chr4:58628142-58663561 (+)
CBA/J ENSMUSG00210005824
 protein coding gene Chr4:58554258-58581926 (+)
DBA/2J ENSMUSG00185016643
 protein coding gene Chr4:58975734-58999783 (+)
FVB/NJ ENSMUSG00205015599
 protein coding gene Chr4:57243311-57270972 (+)
JF1/MsJ ENSUMUG00000024605
 protein coding gene Chr4:59618789-59643163 (+)
LP/J ENSMUSG00230010025
 protein coding gene Chr4:62461341-62488917 (+)
NOD/ShiLtJ ENSMUSG00190034841
 protein coding gene Chr4:57952904-57980575 (+)
NZO/HlLtJ ENSMUSG00225013437
 protein coding gene Chr4:67489544-67517206 (+)
PWK/PhJ ENSLUMG00010007424
 protein coding gene Chr4:57251675-57276316 (+)
SPRET/EiJ ENSMSPG00010031282
 protein coding gene Chr4:58520300-58542966 (+)
WSB/EiJ ENSIUOG00005021282
 protein coding gene Chr4:58308700-58336289 (+)



Homology
more
  • Human Ortholog
    TMEM268, transmembrane protein 268
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM268, transmembrane protein 268
  • Synonyms
    C9orf91
  • Links
    NCBI Gene ID: 203197
    UniProt: Q5VZI3

  • Chr Location
    9q32; chr9:114603904-114646422 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null mutation display increased susceptibility to induced sepsis and impaired phagocyte adhesion, migration, and phagocytosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045917 Ensembl Gene Model | MGI Sequence Detail 27577 C57BL/6J ±  kb
    transcript ENSMUST00000077709 Ensembl | MGI Sequence Detail 3765 Not Applicable  
    polypeptide ENSMUSP00000076891 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140577
    References
    more
    • Summaries
      All 30
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350812 Duan M, et al., Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling. EMBO Rep. 2024 Jun;25(6):2550-2570
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory