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Spc25 Gene Detail
Summary
  • Symbol
    Spc25
  • Name
    SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
  • Synonyms
    2600017H08Rik, 2610205L13Rik, Spbc25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913692
    NCBI Gene: 66442
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69024239-69036538 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.64 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913692
 protein coding gene Chr2:69009753-69036583 (-)
129S1/SvImJ ENSMUSG00200036202
 protein coding gene Chr2:66073106-66085423 (-)
A/J ENSMUSG00195021521
 protein coding gene Chr2:66219984-66232739 (-)
AKR/J ENSMUSG00220038137
 protein coding gene Chr2:66187083-66199838 (-)
BALB/cJ ENSMUSG00180040932
 protein coding gene Chr2:66180603-66192905 (-)
C3H/HeJ ENSMUSG00175032368
 protein coding gene Chr2:66289536-66301855 (-)
C57BL/6NJ ENSMUSG00215026561
 protein coding gene Chr2:66119911-66132213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023617
 protein coding gene Chr2:63710766-63721879 (-)
CAST/EiJ ENSTCUG00005008923
 protein coding gene Chr2:65581911-65594414 (-)
CBA/J ENSMUSG00210037161
 protein coding gene Chr2:66329812-66342131 (-)
DBA/2J ENSMUSG00185037826
 protein coding gene Chr2:66175781-66188080 (-)
FVB/NJ ENSMUSG00205019976
 protein coding gene Chr2:65634929-65647684 (-)
JF1/MsJ ENSUMUG00000003078
 protein coding gene Chr2:65836277-65848686 (-)
LP/J ENSMUSG00230019795
 protein coding gene Chr2:67981364-67993663 (-)
NOD/ShiLtJ ENSMUSG00190037986
 protein coding gene Chr2:66253785-66266545 (-)
NZO/HlLtJ ENSMUSG00225014833
 protein coding gene Chr2:75716226-75728981 (-)
PWK/PhJ ENSLUMG00010029293
 protein coding gene Chr2:66053540-66065921 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005019070
 protein coding gene Chr2:66301869-66314628 (-)



Homology
more
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
  • Synonyms
    AD024, hSpc25, SPBC25
  • Links
    NCBI Gene ID: 57405
    UniProt: Q9HBM1

  • Chr Location
    2q24.3; chr2:168834132-168913371 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    58
  • cDNA Data
    13
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005233 Ensembl Gene Model | MGI Sequence Detail 12300 C57BL/6J ±  kb
transcript ENSMUST00000112320 Ensembl | MGI Sequence Detail 1527 Not Applicable  
polypeptide ENSMUSP00000107939 Ensembl | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919740
References
more
  • Summaries
    All 50
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory