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Cyb5b Gene Detail
Summary
  • Symbol
    Cyb5b
  • Name
    cytochrome b5 type B
  • Synonyms
    1810044O22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913677
    NCBI Gene: 66427
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107877293-107914102 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.71 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    930 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913677
 protein coding gene Chr8:107877272-107914103 (+)
129S1/SvImJ ENSMUSG00200013108
 protein coding gene Chr8:102158578-102195471 (+)
A/J ENSMUSG00195016520
 protein coding gene Chr8:102480964-102517864 (+)
AKR/J ENSMUSG00220014393
 protein coding gene Chr8:102619956-102656854 (+)
BALB/cJ ENSMUSG00180019527
 protein coding gene Chr8:102486740-102523640 (+)
C3H/HeJ ENSMUSG00175024459
 protein coding gene Chr8:102543751-102580644 (+)
C57BL/6NJ ENSMUSG00215017722
 protein coding gene Chr8:102156912-102193743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031533
 protein coding gene Chr8:98275351-98313180 (+)
CAST/EiJ ENSTCUG00005032285
 protein coding gene Chr8:101911785-101948149 (+)
CBA/J ENSMUSG00210030102
 protein coding gene Chr8:102471086-102507979 (+)
DBA/2J ENSMUSG00185004823
 protein coding gene Chr8:108579843-108616736 (+)
FVB/NJ ENSMUSG00205015217
 protein coding gene Chr8:101454659-101491556 (+)
JF1/MsJ ENSUMUG00000005650
 protein coding gene Chr8:110913008-110949907 (+)
LP/J ENSMUSG00230034620
 protein coding gene Chr8:112260109-112297002 (+)
NOD/ShiLtJ ENSMUSG00190021017
 protein coding gene Chr8:102605302-102642194 (+)
NZO/HlLtJ ENSMUSG00225019178
 protein coding gene Chr8:115610696-115647589 (+)
PWK/PhJ ENSLUMG00010025488
 protein coding gene Chr8:102391649-102428203 (+)
SPRET/EiJ ENSMSPG00010039076
 protein coding gene Chr8:104459875-104493457 (+)
WSB/EiJ ENSIUOG00005027626
 protein coding gene Chr8:103289797-103326796 (+)



Homology
more
  • Human Ortholog
    CYB5B, cytochrome b5 type B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYB5B, cytochrome b5 type B
  • Synonyms
    CYB5-M, CYPB5M, OMB5
  • Links
    NCBI Gene ID: 80777
    UniProt: O43169

  • Chr Location
    16q22.1; chr16:69398402-69466264 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    11
  • cDNA Data
    288
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66427 NCBI Gene Model | MGI Sequence Detail 36810 C57BL/6J ±  kb
    transcript NM_025558 RefSeq | MGI Sequence Detail 4294 C57BL/6  
    polypeptide Q9CQX2 UniProt | EBI | MGI Sequence Detail 146 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 288
      cDNA 288

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2142677
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:365675 Ma MY, et al., Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols. Cell Rep. 2024 Nov 26;43(11):114912
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory