About   Help   FAQ
Sac3d1 Gene Detail
Summary
  • Symbol
    Sac3d1
  • Name
    SAC3 domain containing 1
  • Synonyms
    2410004C24Rik, Shd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913656
    NCBI Gene: 66406
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6166030-6168680 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913656
 protein coding gene Chr19:6166025-6168689 (-)
129S1/SvImJ ENSMUSG00200043123
 protein coding gene Chr19:2928457-2931107 (-)
A/J ENSMUSG00195049206
 protein coding gene Chr19:3336295-3338945 (-)
AKR/J ENSMUSG00220049343
 protein coding gene Chr19:3102283-3104933 (-)
BALB/cJ ENSMUSG00180042116
 protein coding gene Chr19:3703875-3706525 (-)
C3H/HeJ ENSMUSG00175011362
 protein coding gene Chr19:2954044-2956694 (-)
C57BL/6NJ ENSMUSG00215044616
 protein coding gene Chr19:3166789-3169439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022595
 protein coding gene Chr19:2903842-2906884 (-)
CAST/EiJ ENSTCUG00005041731
 protein coding gene Chr19:3088940-3091596 (-)
CBA/J ENSMUSG00210038807
 protein coding gene Chr19:2956755-2959405 (-)
DBA/2J ENSMUSG00185044608
 protein coding gene Chr19:3333230-3335880 (-)
FVB/NJ ENSMUSG00205050481
 protein coding gene Chr19:3335415-3338065 (-)
JF1/MsJ ENSUMUG00000017218
 protein coding gene Chr19:3302457-3305111 (-)
LP/J ENSMUSG00230052907
 protein coding gene Chr19:4235335-4237985 (-)
NOD/ShiLtJ ENSMUSG00190023775
 protein coding gene Chr19:2863623-2866273 (-)
NZO/HlLtJ ENSMUSG00225025069
 protein coding gene Chr19:7944142-7946792 (-)
PWK/PhJ ENSLUMG00010003999
 protein coding gene Chr19:3070235-3072890 (-)
SPRET/EiJ ENSMSPG00010047234
 protein coding gene Chr19:3064466-3067134 (-)
WSB/EiJ ENSIUOG00005040425
 protein coding gene Chr19:2977004-2979654 (-)



Homology
more
  • Human Ortholog
    SAC3D1, SAC3 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAC3D1, SAC3 domain containing 1
  • Synonyms
    HSU79266, SHD1
  • Links
    NCBI Gene ID: 29901
    UniProt: A6NKF1

  • Chr Location
    11q13.1; chr11:65040901-65044828 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygote for a null allele had increased numbers of myeloid and erythroid progenitor cells. Mice homozygote for a null allele had these features plus mild spleen and thymus hyperplasia, an increased T cell proliferative response, and enhanced IgM secretion by B cells to IL-5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    12
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024790 Ensembl Gene Model | MGI Sequence Detail 2651 C57BL/6J ±  kb
    transcript ENSMUST00000113533 Ensembl | MGI Sequence Detail 1442 Not Applicable  
    polypeptide ENSMUSP00000109161 Ensembl | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147639
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory