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Psenen Gene Detail
Summary
  • Symbol
    Psenen
  • Name
    presenilin enhancer gamma secretase subunit
  • Synonyms
    1700023M09Rik, Pen2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913590
    NCBI Gene: 66340
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30261290-30263052 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.60 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913590
 protein coding gene Chr7:30261288-30263052 (-)
129S1/SvImJ ENSMUSG00200004860
 protein coding gene Chr4:37616770-37617596 (-)
129S1/SvImJ ENSMUSG00200023285
 protein coding gene Chr7:20041528-20043292 (-)
A/J ENSMUSG00195044878
 protein coding gene Chr7:22710360-22712123 (-)
A/J ENSMUSG00195003007
 protein coding gene Chr4:37992558-37993376 (-)
AKR/J ENSMUSG00220029297
 protein coding gene Chr4:37820633-37821451 (-)
AKR/J ENSMUSG00220045502
 protein coding gene Chr7:21769138-21770901 (+)
BALB/cJ ENSMUSG00180015999
 protein coding gene Chr7:20769837-20771600 (-)
BALB/cJ ENSMUSG00180025484
 protein coding gene Chr4:37579394-37580221 (-)
C3H/HeJ ENSMUSG00175022099
 protein coding gene Chr4:37958042-37958859 (-)
C3H/HeJ ENSMUSG00175030044
 protein coding gene Chr7:21850319-21852083 (-)
C57BL/6NJ ENSMUSG00215022536
 protein coding gene Chr4:37595663-37596488 (-)
C57BL/6NJ ENSMUSG00215052510
 protein coding gene Chr7:19952447-19954211 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029528
 protein coding gene Chr7:29794420-29795705 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210025335
 protein coding gene Chr7:21012927-21014691 (-)
CBA/J ENSMUSG00210007437
 protein coding gene Chr4:37659006-37659832 (-)
DBA/2J ENSMUSG00185006437
 protein coding gene Chr4:37732749-37733573 (-)
DBA/2J ENSMUSG00185047115
 protein coding gene Chr7:24101126-24102884 (-)
FVB/NJ ENSMUSG00205011294
 protein coding gene Chr7:20761944-20763708 (-)
FVB/NJ ENSMUSG00205023774
 protein coding gene Chr4:37283466-37284292 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230052119
 protein coding gene Chr7:29271576-29273334 (-)
LP/J ENSMUSG00230041502
 protein coding gene Chr4:41110385-41111211 (-)
NOD/ShiLtJ ENSMUSG00190005339
 protein coding gene Chr4:37681960-37682777 (-)
NOD/ShiLtJ ENSMUSG00190007807
 protein coding gene Chr7:20434781-20436542 (-)
NZO/HlLtJ ENSMUSG00225006491
 protein coding gene Chr4:44990992-44991794 (-)
NZO/HlLtJ ENSMUSG00225026281
 protein coding gene Chr7:28111982-28113735 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033695
 protein coding gene Chr7:19839664-19841422 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PSENEN, presenilin enhancer, gamma-secretase subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSENEN, presenilin enhancer, gamma-secretase subunit
  • Synonyms
    ACNINV2, MDS033, MSTP064, PEN-2, PEN2
  • Links
    NCBI Gene ID: 55851
    UniProt: Q9NZ42

  • Chr Location
    19q13.12; chr19:35745070-35747519 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSENEN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    20
  • cDNA Data
    112
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66340 NCBI Gene Model | MGI Sequence Detail 1763 C57BL/6J ±  kb
transcript NM_025498 RefSeq | MGI Sequence Detail 671 C57BL/6  
polypeptide Q9CQR7 UniProt | EBI | MGI Sequence Detail 101 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013346 gamma-secretase subunit PEN-2
    (term hierarchy)
  • InterPro Domains
    IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Molecular
Reagents
less
  • All nucleic 112
    cDNA 112

    Microarray probesets 4
References
more
  • Summaries
    All 61
    Developmental Gene Expression 11
    Gene Ontology 17
    Phenotypes 15
  • Earliest
    J:54336 De Strooper B, et al., A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [see comments]. Nature. 1999 Apr 8;398(6727):518-22
  • Latest
    J:372758 Bi H, et al., Pen-2 regulates glial homeostasis by coordinating self-renewal and transdifferentiation programs in oligodendrocyte precursor cells. Stem Cell Reports. 2025 Sep 9;20(9):102612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory