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Ssr2 Gene Detail
Summary
  • Symbol
    Ssr2
  • Name
    signal sequence receptor, beta
  • Synonyms
    TRAPbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913506
    NCBI Gene: 66256
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88486915-88495727 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913506
 protein coding gene Chr3:88483183-88495727 (+)
129S1/SvImJ ENSMUSG00200037173
 protein coding gene Chr3:85338071-85350617 (+)
A/J ENSMUSG00195050335
 protein coding gene Chr3:85359922-85372761 (+)
AKR/J ENSMUSG00220047806
 protein coding gene Chr3:85314827-85327370 (+)
BALB/cJ ENSMUSG00180040664
 protein coding gene Chr3:85484571-85497109 (+)
C3H/HeJ ENSMUSG00175036188
 protein coding gene Chr3:85292976-85305514 (+)
C57BL/6NJ ENSMUSG00215047716
 protein coding gene Chr3:85725833-85738374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025174
 protein coding gene Chr3:81353758-81369167 (+)
CAST/EiJ ENSTCUG00005047082
 protein coding gene Chr3:84814864-84822860 (+)
CBA/J ENSMUSG00210034656
 protein coding gene Chr3:85430660-85443198 (+)
DBA/2J ENSMUSG00185049883
 protein coding gene Chr3:85573119-85585656 (+)
FVB/NJ ENSMUSG00205046590
 protein coding gene Chr3:84354600-84367142 (+)
JF1/MsJ ENSUMUG00000013236
 protein coding gene Chr3:85094392-85106960 (+)
LP/J ENSMUSG00230028749
 protein coding gene Chr3:87559440-87571983 (+)
NOD/ShiLtJ ENSMUSG00190042213
 protein coding gene Chr3:85806763-85819305 (+)
NZO/HlLtJ ENSMUSG00225007070
 protein coding gene Chr3:90321957-90334500 (+)
PWK/PhJ ENSLUMG00010041784
 protein coding gene Chr3:85183801-85196447 (+)
SPRET/EiJ ENSMSPG00010047414
 protein coding gene Chr3:86031827-86041681 (+)
WSB/EiJ ENSIUOG00005046438
 protein coding gene Chr3:85835282-85847818 (+)



Homology
more
  • Human Ortholog
    SSR2, signal sequence receptor subunit 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSR2, signal sequence receptor subunit 2
  • Synonyms
    HSD25, TLAP, TRAPB, TRAP-BETA
  • Links
    NCBI Gene ID: 6746
    UniProt: P43308

  • Chr Location
    1q22; chr1:156009041-156020968 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal placental labyrinth vasculature morphology, perimembraneous ventricular septal defects, abnormal forebrain morphology, and complete preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    644
  • Tissues
    24
  • cDNA Data
    246
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66256 NCBI Gene Model | MGI Sequence Detail 8813 C57BL/6J ±  kb
    transcript NM_025448 RefSeq | MGI Sequence Detail 1253 C57BL/6  
    polypeptide Q9CPW5 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000015660 translocon-associated protein subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR008856 Translocon-associated protein subunit beta
    • GlyGen
      Q9CPW5 2 sites, 9 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 248
      cDNA 246
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139666, MGI:2139881
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 3
      Phenotypes 23
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory