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Kcne5 Gene Detail
Summary
  • Symbol
    Kcne5
  • Name
    potassium voltage-gated channel subfamily E regulatory subunit 5
  • Synonyms
    1500015C14Rik, Kcne1l, Kcne5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913490
    NCBI Gene: 66240
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:141087749-141089194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 63.11 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913490
 protein coding gene ChrX:141087748-141089290 (-)
129S1/SvImJ ENSMUSG00200045931
 protein coding gene ChrX:120100554-120102096 (-)
A/J ENSMUSG00195046210
 protein coding gene ChrX:123962801-123964343 (-)
AKR/J ENSMUSG00220034877
 protein coding gene ChrX:117392887-117394429 (-)
BALB/cJ ENSMUSG00180034738
 protein coding gene ChrX:120392914-120394456 (-)
C3H/HeJ ENSMUSG00175032741
 protein coding gene ChrX:124253141-124254683 (-)
C57BL/6NJ ENSMUSG00215044110
 protein coding gene ChrX:120855477-120857019 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033464
 protein coding gene ChrX:130771426-130772966 (-)
CAST/EiJ ENSTCUG00005037807
 protein coding gene ChrX:121485193-121486735 (-)
CBA/J ENSMUSG00210031009
 protein coding gene ChrX:121182038-121183580 (-)
DBA/2J ENSMUSG00185032807
 protein coding gene ChrX:135072945-135074487 (-)
FVB/NJ ENSMUSG00205023129
 protein coding gene ChrX:119576749-119578291 (-)
JF1/MsJ ENSUMUG00000030039
 protein coding gene ChrX:154350192-154351734 (-)
LP/J ENSMUSG00230037215
 protein coding gene ChrX:141701266-141702808 (-)
NOD/ShiLtJ ENSMUSG00190035628
 protein coding gene ChrX:120578370-120579912 (-)
NZO/HlLtJ ENSMUSG00225042587
 protein coding gene ChrX:146392665-146394207 (-)
PWK/PhJ ENSLUMG00010042083
 protein coding gene ChrX:119057741-119059283 (-)
SPRET/EiJ ENSMSPG00010037987
 protein coding gene ChrX:123770773-123772315 (-)
WSB/EiJ ENSIUOG00005037637
 protein coding gene ChrX:121228249-121229791 (-)



Homology
more
  • Human Ortholog
    KCNE5, potassium voltage-gated channel subfamily E regulatory subunit 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNE5, potassium voltage-gated channel subfamily E regulatory subunit 5
  • Synonyms
    KCNE1L
  • Links
    NCBI Gene ID: 23630
    UniProt: Q9UJ90

  • Chr Location
    Xq23; chrX:109623700-109625172 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for null alleles show ventricular arrhythmia (ventricular premature beat), increased susceptibility to induction of polymorphic ventricular tachycardia, shorter ventricular refractory period, and augmented ventricular potassium currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    704
  • Tissues
    24
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66240 NCBI Gene Model | MGI Sequence Detail 1446 C57BL/6J ±  kb
    transcript NM_021487 RefSeq | MGI Sequence Detail 1446 Not Specified  
    polypeptide Q9QZ26 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031113 potassium voltage-gated channel subfamily E regulatory beta subunit 5
      (term hierarchy)
    • InterPro Domains
      IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
    • GlyGen
      Q9QZ26 2 sites, 1 N-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:7482245
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 4
    • Earliest
      J:57928 Piccini M, et al., KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs. Genomics. 1999 Sep 15;60(3):251-7
    • Latest
      J:313609 Diaz Del Moral S, et al., Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021;9:683861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory