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Dnajc15 Gene Detail
Summary
  • Symbol
    Dnajc15
  • Name
    DnaJ heat shock protein family (Hsp40) member C15
  • Synonyms
    1110003P16Rik, Dnajd1, MCJ
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913398
    NCBI Gene: 66148
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78063657-78112357 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 41.04 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913398
 protein coding gene Chr14:78058121-78112565 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021586
 protein coding gene Chr14:72840688-72896376 (-)
A/J MGP_AJ_G0021544
 protein coding gene Chr14:71111355-71159690 (-)
AKR/J MGP_AKRJ_G0021521
 protein coding gene Chr14:73220752-73270328 (-)
BALB/cJ MGP_BALBcJ_G0021551
 protein coding gene Chr14:70915056-70963216 (-)
C3H/HeJ MGP_C3HHeJ_G0021328
 protein coding gene Chr14:72933867-72983220 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021991
 protein coding gene Chr14:75962431-76039807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019529
 protein coding gene Chr14:68683937-68737711 (-)
CAST/EiJ MGP_CASTEiJ_G0020845
 protein coding gene Chr14:69707643-69763304 (-)
CBA/J MGP_CBAJ_G0021296
 protein coding gene Chr14:78415647-78468315 (-)
DBA/2J MGP_DBA2J_G0021419
 protein coding gene Chr14:70497331-70546047 (-)
FVB/NJ MGP_FVBNJ_G0021397
 protein coding gene Chr14:69840012-69888070 (-)
LP/J MGP_LPJ_G0021489
 protein coding gene Chr14:73965292-74020278 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021424
 protein coding gene Chr14:77067306-77125874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022014
 protein coding gene Chr14:72512401-72562751 (-)
PWK/PhJ MGP_PWKPhJ_G0020588
 protein coding gene Chr14:67272398-67325488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020425
 protein coding gene Chr14:68477617-68535707 (-)
WSB/EiJ MGP_WSBEiJ_G0020898
 protein coding gene Chr14:72842836-72893194 (-)



Homology
more
  • Human Ortholog
    DNAJC15, DnaJ heat shock protein family (Hsp40) member C15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJC15, DnaJ heat shock protein family (Hsp40) member C15
  • Synonyms
    DNAJD1, HSD18, MCJ
  • Links
    NCBI Gene ID: 29103
    neXtProt AC: NX_Q9Y5T4
    UniProt: Q9Y5T4

  • Chr Location
    13q14.11; chr13:43023203-43114213 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased mitochondrial activity that results in rapid metabolism in fasted mice or mice fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    49
  • cDNA Data
    81
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66148 NCBI Gene Model | MGI Sequence Detail 48701 C57BL/6J ±  kb
    transcript NM_025384 RefSeq | MGI Sequence Detail 671 C57BL/6  
    polypeptide Q78YY6 UniProt | EBI | MGI Sequence Detail 149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 2
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344327 Santamans AM, et al., MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension. Sci Adv. 2024 Jan 19;10(3):eadk6524
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory