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Psrc1 Gene Detail
Summary
  • Symbol
    Psrc1
  • Name
    proline/serine-rich coiled-coil 1
  • Synonyms
    5430413I02Rik, DDA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913099
    NCBI Gene: 56742
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108291155-108295547 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913099
 protein coding gene Chr3:108291120-108295547 (+)
129S1/SvImJ ENSMUSG00200034852
 protein coding gene Chr3:104907168-104911559 (+)
A/J ENSMUSG00195025111
 protein coding gene Chr3:105333634-105338025 (+)
AKR/J ENSMUSG00220028459
 protein coding gene Chr3:103697269-103701660 (+)
BALB/cJ ENSMUSG00180015814
 protein coding gene Chr3:105279691-105284081 (+)
C3H/HeJ ENSMUSG00175029167
 protein coding gene Chr3:104813723-104818114 (+)
C57BL/6NJ ENSMUSG00215024311
 protein coding gene Chr3:105541602-105545993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025529
 protein coding gene Chr3:102591973-102596591 (+)
CAST/EiJ ENSTCUG00005024702
 protein coding gene Chr3:105815041-105819496 (+)
CBA/J ENSMUSG00210007498
 protein coding gene Chr3:105435599-105439990 (+)
DBA/2J ENSMUSG00185019837
 protein coding gene Chr3:105904937-105909328 (+)
FVB/NJ ENSMUSG00205017977
 protein coding gene Chr3:104471592-104475984 (+)
JF1/MsJ ENSUMUG00000004446
 protein coding gene Chr3:104875138-104879562 (+)
LP/J ENSMUSG00230019558
 protein coding gene Chr3:107820162-107824552 (+)
NOD/ShiLtJ ENSMUSG00190026938
 protein coding gene Chr3:106143007-106147398 (+)
NZO/HlLtJ ENSMUSG00225016021
 protein coding gene Chr3:110320861-110325297 (+)
PWK/PhJ ENSLUMG00010023777
 protein coding gene Chr3:104738985-104743423 (+)
SPRET/EiJ ENSMSPG00010033477
 protein coding gene Chr3:105243792-105248642 (+)
WSB/EiJ ENSIUOG00005004084
 protein coding gene Chr3:105459311-105463701 (+)



Homology
more
  • Human Ortholog
    PSRC1, proline and serine rich coiled-coil 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSRC1, proline and serine rich coiled-coil 1
  • Synonyms
    DDA3, FP3214
  • Links
    NCBI Gene ID: 84722
    UniProt: Q6PGN9

  • Chr Location
    1p13.3; chr1:109279545-109284107 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Psrc1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    22 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    16
  • cDNA Data
    99
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068744 Ensembl Gene Model | MGI Sequence Detail 4393 C57BL/6J ±  kb
transcript ENSMUST00000090561 Ensembl | MGI Sequence Detail 1686 Not Applicable  
polypeptide ENSMUSP00000088049 Ensembl | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013406 proline/serine-rich coiled-coil protein 1
    (term hierarchy)
  • InterPro Domains
    IPR032768 G2 and S phase-expressed protein 1, N-terminal
    IPR026657 Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1
  • GlyGen
    Q9D0P7 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 99
    cDNA 99

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914808, MGI:2139859
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:64940 Lo PK, et al., Identification of a novel mouse p53 target gene DDA3. Oncogene. 1999 Dec 16;18(54):7765-74
  • Latest
    J:345389 Pan H, et al., Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2. Clin Transl Med. 2023 Mar;13(3):e1220
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory