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Ms4a4b Gene Detail
Summary
  • Symbol
    Ms4a4b
  • Name
    membrane-spanning 4-domains, subfamily A, member 4B
  • Synonyms
    Chandra, Ly116
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913083
    NCBI Gene: 60361
  • Member of
    Ms4ac cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11420922-11440913 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.44 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913083
 protein coding gene Chr19:11420917-11444419 (+)
129S1/SvImJ ENSMUSG00200043217
 protein coding gene Chr19:8100934-8124416 (+)
A/J ENSMUSG00195050481
 protein coding gene Chr19:8305282-8328773 (+)
AKR/J ENSMUSG00220043794
 protein coding gene Chr19:8216056-8239541 (+)
BALB/cJ ENSMUSG00180037631
 protein coding gene Chr19:8669867-8693356 (+)
C3H/HeJ ENSMUSG00175010810
 protein coding gene Chr19:7946629-7970117 (+)
C57BL/6NJ ENSMUSG00215037368
 protein coding gene Chr19:8018242-8041727 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005029486
 protein coding gene Chr19:7794433-7817742 (+)
CBA/J ENSMUSG00210037623
 protein coding gene Chr19:8145149-8168637 (+)
DBA/2J ENSMUSG00185045091
 protein coding gene Chr19:8555176-8578662 (+)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000054639
 protein coding gene Chr19:8674837-8698345 (+)
LP/J ENSMUSG00230053476
 protein coding gene Chr19:9475512-9498994 (+)
NOD/ShiLtJ ENSMUSG00190049921
 protein coding gene Chr19:7767941-7791429 (+)
NZO/HlLtJ ENSMUSG00225045042
 protein coding gene Chr19:13184439-13207921 (+)
PWK/PhJ ENSLUMG00010007540
 protein coding gene Chr19:8075905-8099453 (+)
SPRET/EiJ ENSMSPG00010041727
 protein coding gene Chr19:7900003-7918761 (+)
WSB/EiJ ENSIUOG00005050019
 protein coding gene Chr19:7636309-7655436 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    35
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 60361 NCBI Gene Model | MGI Sequence Detail 19992 C57BL/6J ±  kb
transcript NM_021718 RefSeq | MGI Sequence Detail 1282 C57BL/6  
polypeptide NP_068364 RefSeq | MGI Sequence Detail 226 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR007237 CD20-like, transmembrane domain
    IPR030417 Membrane-spanning 4-domains subfamily A
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147556
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65151 Venkataraman C, et al., Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J Immunol. 2000 Jul 15;165(2):632-6
  • Latest
    J:360865 Jiang HC, et al., CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators. Nat Commun. 2024 Apr 18;15(1):3360
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory