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Fgf23 Gene Detail
Summary
  • Symbol
    Fgf23
  • Name
    fibroblast growth factor 23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891427
    NCBI Gene: 64654
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127049865-127058371 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891427
 protein coding gene Chr6:127049865-127059257 (+)
129S1/SvImJ ENSMUSG00200044460
 protein coding gene Chr6:124123452-124131957 (+)
A/J ENSMUSG00195028887
 protein coding gene Chr6:123552968-123561454 (+)
AKR/J ENSMUSG00220031747
 protein coding gene Chr6:122414572-122423064 (+)
BALB/cJ ENSMUSG00180036902
 protein coding gene Chr6:123889957-123898446 (+)
C3H/HeJ ENSMUSG00175033242
 protein coding gene Chr6:123553661-123562149 (+)
C57BL/6NJ ENSMUSG00215016078
 protein coding gene Chr6:123879433-123887942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028894
 protein coding gene Chr6:122772264-122780880 (+)
CAST/EiJ ENSTCUG00005037739
 protein coding gene Chr6:123727955-123736447 (+)
CBA/J ENSMUSG00210015708
 protein coding gene Chr6:123590240-123598725 (+)
DBA/2J ENSMUSG00185039291
 protein coding gene Chr6:124290545-124299037 (+)
FVB/NJ ENSMUSG00205024165
 protein coding gene Chr6:123162026-123170512 (+)
JF1/MsJ ENSUMUG00000045048
 protein coding gene Chr6:122705840-122714243 (+)
LP/J ENSMUSG00230038950
 protein coding gene Chr6:125487724-125496214 (+)
NOD/ShiLtJ ENSMUSG00190026304
 protein coding gene Chr6:123266023-123274472 (+)
NZO/HlLtJ ENSMUSG00225015189
 protein coding gene Chr6:127520887-127529354 (+)
PWK/PhJ ENSLUMG00010048346
 protein coding gene Chr6:121956207-121964657 (+)
SPRET/EiJ ENSMSPG00010037159
 protein coding gene Chr6:124810911-124818678 (+)
WSB/EiJ ENSIUOG00005043318
 protein coding gene Chr6:123976347-123984818 (+)



Homology
more
  • Human Ortholog
    FGF23, fibroblast growth factor 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF23, fibroblast growth factor 23
  • Synonyms
    ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC
  • Links
    NCBI Gene ID: 8074
    UniProt: Q9GZV9

  • Chr Location
    12p13.32; chr12:4368227-4379712 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgf23 mouse models; 1 with human FGF23 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 5 alleles in 7 genetic backgrounds
    30 phenotypes from multigenic genotypes
    2 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are severely growth retarded and die prematurely. They exhibit hypophosphatemia, abnormal vitamin D metabolism, renal defects, skeletal defects, and are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    179
  • cDNA Data
    7
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000182 Ensembl Gene Model | MGI Sequence Detail 8507 C57BL/6J ±  kb
    transcript ENSMUST00000000186 Ensembl | MGI Sequence Detail 1814 Not Applicable  
    polypeptide ENSMUSP00000000186 Ensembl | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 7
      Primer pair 5
      Other 5
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 365
      Developmental Gene Expression 22
      Diseases 3
      Gene Ontology 12
      Phenotypes 70
    • Earliest
      J:65463 White KE, et al., Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000 Nov;26(3):345-8
    • Latest
      J:385746 Ay B, et al., Lysophosphatidic Acid Synergizes With 1,25-Dihydroxyvitamin D to Promote Fibroblast Growth Factor-23 Synthesis via MAPK Signaling and Induction of the IL12A Gene. FASEB J. 2026 Jan 15;40(1):e71435
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory