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Mesd Gene Detail
Summary
  • Symbol
    Mesd
  • Name
    mesoderm development LRP chaperone
  • Synonyms
    2210015O11Rik, Mesdc2, mKIAA0081, msd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891421
    NCBI Gene: 67943
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:83533074-83549519 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    450 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891421
 protein coding gene Chr7:83533074-83550740 (+)
129S1/SvImJ ENSMUSG00200033730
 protein coding gene Chr7:70348240-70361169 (+)
A/J ENSMUSG00195040389
 protein coding gene Chr7:74807032-74819961 (+)
AKR/J ENSMUSG00220034542
 protein coding gene Chr7:68325249-68338175 (+)
BALB/cJ ENSMUSG00180034261
 protein coding gene Chr7:71512650-71525581 (+)
C3H/HeJ ENSMUSG00175033702
 protein coding gene Chr7:72260279-72273202 (+)
C57BL/6NJ ENSMUSG00215013834
 protein coding gene Chr7:71367379-71380574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029944
 protein coding gene Chr7:86336520-86353710 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210038956
 protein coding gene Chr7:72122542-72135468 (+)
DBA/2J ENSMUSG00185045329
 protein coding gene Chr7:76434382-76446864 (+)
FVB/NJ ENSMUSG00205019466
 protein coding gene Chr7:72063418-72076345 (+)
JF1/MsJ ENSUMUG00000017315
 protein coding gene Chr7:81119249-81131292 (+)
LP/J ENSMUSG00230014899
 protein coding gene Chr7:82523335-82536260 (+)
NOD/ShiLtJ ENSMUSG00190023025
 protein coding gene Chr7:72269701-72282629 (+)
NZO/HlLtJ ENSMUSG00225010041
 protein coding gene Chr7:80798633-80811386 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010011995
 protein coding gene Chr7:71155577-71166047 (+)
WSB/EiJ ENSIUOG00005032081
 protein coding gene Chr7:72608418-72621351 (+)



Homology
more
  • Human Ortholog
    MESD, mesoderm development LRP chaperone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MESD, mesoderm development LRP chaperone
  • Synonyms
    BOCA, MESDC2, OI20
  • Links
    NCBI Gene ID: 23184
    UniProt: Q14696

  • Chr Location
    15q25.1; chr15:80946289-80989834 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MESD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure to form the primitive stream and absence of mesodermal derivatives.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    23
  • cDNA Data
    293
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67943 NCBI Gene Model | MGI Sequence Detail 16446 C57BL/6J ±  kb
    transcript NR_164325 RefSeq | MGI Sequence Detail 3636 C57BL/6  
    polypeptide Q9ERE7 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 295
      cDNA 293
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12201, MGI:1915193, MGI:2142243, MGI:5897381, MGI:96967
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 5
      Gene Ontology 18
      Phenotypes 28
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:287028 Moosa S, et al., Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta. Am J Hum Genet. 2019 Oct 3;105(4):836-843
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory