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Onecut2 Gene Detail
Summary
  • Symbol
    Onecut2
  • Name
    one cut domain, family member 2
  • Synonyms
    Oc2, OC-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891408
    NCBI Gene: 225631
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:64473098-64531559 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.33 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1344 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891408
 protein coding gene Chr18:64473091-64534058 (+)
129S1/SvImJ ENSMUSG00200022788
 protein coding gene Chr18:61654402-61715379 (+)
A/J ENSMUSG00195031383
 protein coding gene Chr18:61706013-61767068 (+)
AKR/J ENSMUSG00220022776
 protein coding gene Chr18:61670218-61731162 (+)
BALB/cJ ENSMUSG00180011061
 protein coding gene Chr18:62272972-62334045 (+)
C3H/HeJ ENSMUSG00175009971
 protein coding gene Chr18:61877374-61938433 (+)
C57BL/6NJ ENSMUSG00215010379
 protein coding gene Chr18:61211925-61272916 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022346
 protein coding gene Chr18:61057606-61115399 (+)
CAST/EiJ ENSTCUG00005015378
 protein coding gene Chr18:60872274-60933250 (+)
CBA/J ENSMUSG00210027474
 protein coding gene Chr18:61835367-61896412 (+)
DBA/2J ENSMUSG00185028388
 protein coding gene Chr18:61739346-61800325 (+)
FVB/NJ ENSMUSG00205009752
 protein coding gene Chr18:61211709-61271961 (+)
JF1/MsJ ENSUMUG00000040633
 protein coding gene Chr18:61626511-61687986 (+)
LP/J ENSMUSG00230036575
 protein coding gene Chr18:63793906-63854881 (+)
NOD/ShiLtJ ENSMUSG00190007928
 protein coding gene Chr18:61469146-61530091 (+)
NZO/HlLtJ ENSMUSG00225029804
 protein coding gene Chr18:63684149-63745161 (+)
PWK/PhJ ENSLUMG00010023274
 protein coding gene Chr18:62034655-62095918 (+)
SPRET/EiJ ENSMSPG00010033715
 protein coding gene Chr18:62176930-62222526 (+)
WSB/EiJ ENSIUOG00005005230
 protein coding gene Chr18:61269886-61330939 (+)



Homology
more
  • Human Ortholog
    ONECUT2, one cut homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ONECUT2, one cut homeobox 2
  • Synonyms
    OC-2, OC2
  • Links
    NCBI Gene ID: 9480
    UniProt: O95948

  • Chr Location
    18q21.31; chr18:57435374-57491298 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal bile duct development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    118
  • cDNA Data
    10
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225631 NCBI Gene Model | MGI Sequence Detail 58462 C57BL/6J ±  kb
    transcript NM_194268 RefSeq | MGI Sequence Detail 13728 C57BL/6  
    polypeptide Q6XBJ3 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 10
      Primer pair 4
      Other 2
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 57
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:75967 Vanhorenbeeck V, et al., OC-3, a Novel Mammalian Member of the ONECUT Class of Transcription Factors. Biochem Biophys Res Commun. 2002 Apr 12;292(4):848-54
    • Latest
      J:382758 Segarra LC, et al., Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors. Sci Adv. 2026 Mar 20;12(12):eadz3075
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory