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Zmpste24 Gene Detail
Summary
  • Symbol
    Zmpste24
  • Name
    zinc metallopeptidase, STE24
  • Synonyms
    A530043O15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890508
    NCBI Gene: 230709
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120916434-120955438 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 56.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    948 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890508
 protein coding gene Chr4:120916434-120955452 (-)
129S1/SvImJ ENSMUSG00200013102
 protein coding gene Chr4:114816400-114855387 (-)
A/J ENSMUSG00195027235
 protein coding gene Chr4:116048257-116087218 (-)
AKR/J ENSMUSG00220021863
 protein coding gene Chr4:115437445-115476434 (-)
BALB/cJ ENSMUSG00180045445
 protein coding gene Chr4:114104249-114143242 (-)
C3H/HeJ ENSMUSG00175024297
 protein coding gene Chr4:115117376-115156364 (-)
C57BL/6NJ ENSMUSG00215033810
 protein coding gene Chr4:116256386-116295391 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026421
 protein coding gene Chr4:111574688-111613885 (-)
CAST/EiJ ENSTCUG00005045468
 protein coding gene Chr4:114931024-114969962 (-)
CBA/J ENSMUSG00210051758
 protein coding gene Chr4:114723814-114762807 (-)
DBA/2J ENSMUSG00185045526
 protein coding gene Chr4:116278849-116317837 (-)
FVB/NJ ENSMUSG00205016556
 protein coding gene Chr4:114205779-114244759 (-)
JF1/MsJ ENSUMUG00000005795
 protein coding gene Chr4:116196382-116235325 (-)
LP/J ENSMUSG00230040401
 protein coding gene Chr4:119634665-119673648 (-)
NOD/ShiLtJ ENSMUSG00190027414
 protein coding gene Chr4:114117213-114156191 (-)
NZO/HlLtJ ENSMUSG00225015588
 protein coding gene Chr4:125187240-125226243 (-)
PWK/PhJ ENSLUMG00010042091
 protein coding gene Chr4:113602212-113640415 (-)
SPRET/EiJ ENSMSPG00010033439
 protein coding gene Chr4:115688619-115728766 (-)
WSB/EiJ ENSIUOG00005045825
 protein coding gene Chr4:114432188-114471538 (-)



Homology
more
  • Human Ortholog
    ZMPSTE24, zinc metallopeptidase STE24
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZMPSTE24, zinc metallopeptidase STE24
  • Synonyms
    FACE-1, FACE1, HGPS, PRO1, RSDM1, STE24, Ste24p
  • Links
    NCBI Gene ID: 10269
    UniProt: O75844

  • Chr Location
    1p34.2; chr1:40258041-40294180 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Zmpste24 mouse models; 3 with human ZMPSTE24 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 2 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    4 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants are deficient in proteolytic processing of prelamin A and display many abnormalities including retarded growth, bone fragility, hair loss, cardiomyopathy, muscular dystrophy and lipodystrophy. Most die prematurely, but some survive and reproduce.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043207 Ensembl Gene Model | MGI Sequence Detail 39005 C57BL/6J ±  kb
    transcript ENSMUST00000058754 Ensembl | MGI Sequence Detail 3429 Not Applicable  
    polypeptide ENSMUSP00000053900 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443572
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 2
      Diseases 5
      Gene Ontology 26
      Phenotypes 66
    • Earliest
      J:70661 Leung GK, et al., Biochemical studies of Zmpste24-deficient mice. J Biol Chem. 2001 Aug 3;276(31):29051-8
    • Latest
      J:387895 Kang YK, et al., Emergence of CpG-cluster blanket methylation in aged tissues: a novel signature of epigenomic aging. Nucleic Acids Res. 2025 May 10;53(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory