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Dxo Gene Detail
Summary
  • Symbol
    Dxo
  • Name
    decapping exoribonuclease
  • Synonyms
    Dom3z
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890444
    NCBI Gene: 112403
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35055998-35058162 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890444
 protein coding gene Chr17:35055995-35058209 (+)
129S1/SvImJ ENSMUSG00200050146
 protein coding gene Chr17:30759405-30761391 (+)
A/J ENSMUSG00195039792
 protein coding gene Chr17:31659645-31661611 (+)
AKR/J ENSMUSG00220049795
 protein coding gene Chr17:30688226-30690215 (+)
BALB/cJ ENSMUSG00180038728
 protein coding gene Chr17:31029514-31031477 (+)
C3H/HeJ ENSMUSG00175033283
 protein coding gene Chr17:30574335-30576329 (+)
C57BL/6NJ ENSMUSG00215050367
 protein coding gene Chr17:30599590-30601578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021476
 protein coding gene Chr17:31571780-31574001 (+)
CAST/EiJ ENSTCUG00005048004
 protein coding gene Chr17:31617812-31619796 (+)
CBA/J ENSMUSG00210052013
 protein coding gene Chr17:30396443-30398436 (+)
DBA/2J ENSMUSG00185050525
 protein coding gene Chr17:33048779-33050741 (+)
FVB/NJ ENSMUSG00205051642
 protein coding gene Chr17:30918204-30920168 (+)
JF1/MsJ ENSUMUG00000056886
 protein coding gene Chr17:32301192-32303208 (+)
LP/J ENSMUSG00230054612
 protein coding gene Chr17:34157668-34159653 (+)
NOD/ShiLtJ ENSMUSG00190051316
 protein coding gene Chr17:30519245-30521220 (+)
NZO/HlLtJ ENSMUSG00225053798
 protein coding gene Chr17:36170684-36172668 (+)
PWK/PhJ ENSLUMG00010051465
 protein coding gene Chr17:30136147-30138123 (+)
SPRET/EiJ ENSMSPG00010047724
 protein coding gene Chr17:31321473-31323657 (+)
WSB/EiJ ENSIUOG00005051082
 protein coding gene Chr17:31246997-31248973 (+)



Homology
more
  • Human Ortholog
    DXO, decapping exoribonuclease
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DXO, decapping exoribonuclease
  • Synonyms
    DOM3L, DOM3Z, NG6
  • Links
    NCBI Gene ID: 1797
    UniProt: O77932

  • Chr Location
    6p21.33; chr6:31969810-31972509 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    41
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 112403 NCBI Gene Model | MGI Sequence Detail 2165 C57BL/6J ±  kb
transcript NM_001413618 RefSeq | MGI Sequence Detail 1487 C57BL/6  
polypeptide O70348 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    Genomic 1
    cDNA 41

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Gene Ontology 9
    Phenotypes 3
  • Earliest
    J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
  • Latest
    J:306600 Doamekpor SK, et al., DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Nucleic Acids Res. 2020 Jun 19;48(11):6136-6148
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory