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Cts6 Gene Detail
Summary
  • Symbol
    Cts6
  • Name
    cathepsin 6
  • Synonyms
    1600022N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889619
    NCBI Gene: 58518
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:61342961-61351206 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 32.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889619
 protein coding gene Chr13:61342946-61351224 (-)
129S1/SvImJ ENSMUSG00200016354
 protein coding gene Chr13:58287314-58295594 (-)
A/J ENSMUSG00195038718
 protein coding gene Chr13:57749500-57757806 (-)
AKR/J ENSMUSG00220035564
 protein coding gene Chr13:57266985-57275265 (-)
BALB/cJ ENSMUSG00180014240
 protein coding gene Chr13:57958884-57967165 (-)
C3H/HeJ ENSMUSG00175039760
 protein coding gene Chr13:57745104-57753382 (-)
C57BL/6NJ ENSMUSG00215037199
 protein coding gene Chr13:57752828-57761106 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018625
 protein coding gene Chr13:56541171-56549202 (-)
CAST/EiJ ENSTCUG00005039507
 protein coding gene Chr13:58116326-58124625 (-)
CBA/J ENSMUSG00210030765
 protein coding gene Chr13:57949961-57958239 (-)
DBA/2J ENSMUSG00185014653
 protein coding gene Chr13:58798600-58806878 (-)
FVB/NJ ENSMUSG00205042037
 protein coding gene Chr13:57532289-57540566 (-)
JF1/MsJ ENSUMUG00000009669
 protein coding gene Chr13:58137730-58145988 (-)
LP/J ENSMUSG00230028711
 protein coding gene Chr13:68158224-68166505 (-)
NOD/ShiLtJ ENSMUSG00190021831
 protein coding gene Chr13:57805256-57813536 (-)
NZO/HlLtJ ENSMUSG00225045233
 protein coding gene Chr13:61849068-61857346 (-)
PWK/PhJ ENSLUMG00010020674
 protein coding gene Chr13:57062866-57071121 (-)
SPRET/EiJ ENSMSPG00010035076
 protein coding gene Chr13:57511081-57519102 (-)
WSB/EiJ ENSIUOG00005025243
 protein coding gene Chr13:57292840-57301120 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    664
  • Tissues
    41
  • cDNA Data
    23
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 58518 NCBI Gene Model | MGI Sequence Detail 8246 C57BL/6J ±  kb
transcript NM_021445 RefSeq | MGI Sequence Detail 1323 ICR  
polypeptide NP_067420 RefSeq | MGI Sequence Detail 334 ICR  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR013201 Cathepsin propeptide inhibitor domain (I29)
    IPR025661 Cysteine peptidase, asparagine active site
    IPR025660 Cysteine peptidase, histidine active site
    IPR039417 Papain-like cysteine endopeptidase
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR013128 Peptidase C1A
    IPR000668 Peptidase C1A, papain C-terminal
Molecular
Reagents
less
  • All nucleic 25
    cDNA 23
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923752
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory