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Api5 Gene Detail
Summary
  • Symbol
    Api5
  • Name
    apoptosis inhibitor 5
  • Synonyms
    AAC-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888993
    NCBI Gene: 11800
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:94242073-94268490 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    626 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888993
 protein coding gene Chr2:94242027-94268490 (-)
129S1/SvImJ ENSMUSG00200053423
 protein coding gene Chr2:91152278-91178754 (-)
A/J ENSMUSG00195000630
 protein coding gene Chr2:91285932-91312422 (-)
AKR/J ENSMUSG00220051157
 protein coding gene Chr2:91074005-91109516 (-)
BALB/cJ ENSMUSG00180020639
 protein coding gene Chr2:91192603-91219074 (-)
C3H/HeJ ENSMUSG00175052980
 protein coding gene Chr2:91438345-91473856 (-)
C57BL/6NJ ENSMUSG00215051144
 protein coding gene Chr2:91286901-91313356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023998
 protein coding gene Chr2:88528860-88555240 (-)
CAST/EiJ ENSTCUG00005052297
 protein coding gene Chr2:90709239-90735715 (-)
CBA/J ENSMUSG00210002158
 protein coding gene Chr2:91464924-91491391 (-)
DBA/2J ENSMUSG00185056818
 protein coding gene Chr2:91188882-91215353 (-)
FVB/NJ ENSMUSG00205050457
 protein coding gene Chr2:90466850-90502362 (-)
JF1/MsJ ENSUMUG00000009733
 protein coding gene Chr2:91015639-91042136 (-)
LP/J ENSMUSG00230000806
 protein coding gene Chr2:92939455-92965926 (-)
NOD/ShiLtJ ENSMUSG00190022106
 protein coding gene Chr2:91267434-91293904 (-)
NZO/HlLtJ ENSMUSG00225052044
 protein coding gene Chr2:100861685-100888153 (-)
PWK/PhJ ENSLUMG00010050852
 protein coding gene Chr2:90975953-91002463 (-)
SPRET/EiJ ENSMSPG00010008773
 protein coding gene Chr2:92970675-92997073 (-)
WSB/EiJ ENSIUOG00005053358
 protein coding gene Chr2:90981205-91007657 (-)



Homology
more
  • Human Ortholog
    API5, apoptosis inhibitor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    API5, apoptosis inhibitor 5
  • Synonyms
    AAC-11, AAC11
  • Links
    NCBI Gene ID: 8539
    UniProt: Q9BZZ5

  • Chr Location
    11p12; chr11:43311955-43344530 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    639
  • Tissues
    29
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11800 NCBI Gene Model | MGI Sequence Detail 26418 C57BL/6J ±  kb
transcript NM_001349003 RefSeq | MGI Sequence Detail 3755 C57BL/6  
polypeptide O35841 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2138859
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:340266 Matsuzawa-Ishimoto Y, et al., The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death. Nature. 2022 Oct;610(7932):547-554
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory