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Retnla Gene Detail
Summary
  • Symbol
    Retnla
  • Name
    resistin like alpha
  • Synonyms
    1810019L16Rik, Fizz-1, Fizz1, HIMF, RELMa, Xcp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888504
    NCBI Gene: 57262
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48662972-48664824 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM, cytoband B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888504
 protein coding gene Chr16:48662914-48664824 (+)
129S1/SvImJ ENSMUSG00200021437
 protein coding gene Chr16:45548607-45550517 (+)
A/J ENSMUSG00195003412
 protein coding gene Chr16:45150240-45152150 (+)
AKR/J ENSMUSG00220022142
 protein coding gene Chr16:45501002-45502912 (+)
BALB/cJ ENSMUSG00180026162
 protein coding gene Chr16:45354943-45356853 (+)
C3H/HeJ ENSMUSG00175024838
 protein coding gene Chr16:45646177-45648088 (+)
C57BL/6NJ ENSMUSG00215006739
 protein coding gene Chr16:45459341-45461251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020795
 protein coding gene Chr16:45748368-45750099 (+)
CAST/EiJ ENSTCUG00005012568
 protein coding gene Chr16:45789469-45791378 (+)
CBA/J ENSMUSG00210016406
 protein coding gene Chr16:45676077-45677988 (+)
DBA/2J ENSMUSG00185010411
 protein coding gene Chr16:45534432-45536342 (+)
FVB/NJ ENSMUSG00205010511
 protein coding gene Chr16:45446811-45448721 (+)
JF1/MsJ ENSUMUG00000021371
 protein coding gene Chr16:45773705-45775618 (+)
LP/J ENSMUSG00230026343
 protein coding gene Chr16:48100787-48102697 (+)
NOD/ShiLtJ ENSMUSG00190017140
 protein coding gene Chr16:45548068-45549978 (+)
NZO/HlLtJ ENSMUSG00225025607
 protein coding gene Chr16:51192616-51194526 (+)
PWK/PhJ ENSLUMG00010026367
 protein coding gene Chr16:45616966-45618878 (+)
SPRET/EiJ ENSMSPG00010007334
 protein coding gene Chr16:45825308-45827216 (+)
WSB/EiJ ENSIUOG00005012947
 protein coding gene Chr16:45751993-45753903 (+)



Homology
more
  • Human Ortholog
    RETNLB, resistin like beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RETNLB, resistin like beta
  • Synonyms
    FIZZ1, FIZZ2, HXCP2, RELMb, RELM-beta, RELMbeta, XCP2
  • Links
    NCBI Gene ID: 84666
    UniProt: Q9BQ08

  • Chr Location
    3q13.13; chr3:108743424-108757410 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 3 genetic backgrounds
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have decreased circulating levels of leptin and are resistant to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    681
  • Tissues
    31
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57262 NCBI Gene Model | MGI Sequence Detail 1853 C57BL/6J ±  kb
    transcript NM_020509 RefSeq | MGI Sequence Detail 541 ZRU/MplStud  
    polypeptide Q9EP95 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Other 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916325
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
    • Latest
      J:373466 Sawhney AS, et al., A molecular circuit regulates fate plasticity in emerging and adult AT2 cells. Nat Commun. 2025 Oct 14;16(1):8924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory