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Psmg1 Gene Detail
Summary
  • Symbol
    Psmg1
  • Name
    proteasome (prosome, macropain) assembly chaperone 1
  • Synonyms
    Dscr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860263
    NCBI Gene: 56088
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95781133-95792160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860263
 protein coding gene Chr16:95781133-95792160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023078
 protein coding gene Chr16:97327639-97340753 (-)
A/J MGP_AJ_G0023046
 protein coding gene Chr16:92709448-92720079 (-)
AKR/J MGP_AKRJ_G0023016
 protein coding gene Chr16:95575030-95585629 (-)
BALB/cJ MGP_BALBcJ_G0023048
 protein coding gene Chr16:93259998-93271672 (-)
C3H/HeJ MGP_C3HHeJ_G0022809
 protein coding gene Chr16:96088381-96102402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023495
 protein coding gene Chr16:100416082-100426846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020997
 protein coding gene Chr16:90569389-90580612 (-)
CAST/EiJ MGP_CASTEiJ_G0022328
 protein coding gene Chr16:96886567-96897447 (-)
CBA/J MGP_CBAJ_G0022778
 protein coding gene Chr16:104740447-104751259 (-)
DBA/2J MGP_DBA2J_G0022912
 protein coding gene Chr16:92600716-92611554 (-)
FVB/NJ MGP_FVBNJ_G0022886
 protein coding gene Chr16:91772626-91783452 (-)
LP/J MGP_LPJ_G0022982
 protein coding gene Chr16:96955168-96966751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022907
 protein coding gene Chr16:108971371-108988487 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023513
 protein coding gene Chr16:96105424-96117434 (-)
PWK/PhJ MGP_PWKPhJ_G0022073
 protein coding gene Chr16:92889407-92901377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021903
 protein coding gene Chr16:95644621-95658021 (-)
WSB/EiJ MGP_WSBEiJ_G0022379
 protein coding gene Chr16:96364225-96375796 (-)



Homology
more
  • Human Ortholog
    PSMG1, proteasome assembly chaperone 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMG1, proteasome assembly chaperone 1
  • Synonyms
    C21LRP, DSCR2, LRPC21, PAC1, PAC-1
  • Links
    NCBI Gene ID: 8624
    neXtProt AC: NX_O95456
    UniProt: O95456

  • Chr Location
    21q22.2; chr21:39174769-39183514 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 5 genetic backgrounds
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die by E6.5. Mice homozygous for a conditional allele activated in the brain exhibit abnormal brain development, neurological defects, and die by P21. Mice homozygous for a conditional allele activated in the liver exhibit premature hepatocyte senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1032
  • Tissues
    110
  • cDNA Data
    81
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56088 NCBI Gene Model | MGI Sequence Detail 11028 C57BL/6J ±  kb
    transcript NM_019537 RefSeq | MGI Sequence Detail 1057 C57BL/6  
    polypeptide Q9JK23 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146658
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 5
      Phenotypes 92
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory