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Pdgfc Gene Detail
Summary
  • Symbol
    Pdgfc
  • Name
    platelet-derived growth factor, C polypeptide
  • Synonyms
    1110064L01Rik, PDGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859631
    NCBI Gene: 54635
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:80943723-81121347 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.73 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6007 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859631
 protein coding gene Chr3:80943723-81121347 (+)
129S1/SvImJ ENSMUSG00200018924
 protein coding gene Chr3:77790539-77968239 (+)
A/J ENSMUSG00195011457
 protein coding gene Chr3:77797827-77975559 (+)
AKR/J ENSMUSG00220001377
 protein coding gene Chr3:77830846-78009304 (+)
BALB/cJ ENSMUSG00180001858
 protein coding gene Chr3:77916919-78095374 (+)
C3H/HeJ ENSMUSG00175007329
 protein coding gene Chr3:77728923-77906616 (+)
C57BL/6NJ ENSMUSG00215001964
 protein coding gene Chr3:78183571-78361220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025093
 protein coding gene Chr3:73951897-74122010 (+)
CAST/EiJ ENSTCUG00005001544
 protein coding gene Chr3:77299692-77471427 (+)
CBA/J ENSMUSG00210025145
 protein coding gene Chr3:77856925-78034624 (+)
DBA/2J ENSMUSG00185012431
 protein coding gene Chr3:78001627-78180106 (+)
FVB/NJ ENSMUSG00205006275
 protein coding gene Chr3:76801215-76976341 (+)
JF1/MsJ ENSUMUG00000001021
 protein coding gene Chr3:77541678-77718407 (+)
LP/J ENSMUSG00230008107
 protein coding gene Chr3:80002998-80180686 (+)
NOD/ShiLtJ ENSMUSG00190002686
 protein coding gene Chr3:78249745-78427395 (+)
NZO/HlLtJ ENSMUSG00225007702
 protein coding gene Chr3:82722275-82901860 (+)
PWK/PhJ ENSLUMG00010006258
 protein coding gene Chr3:77603050-77779761 (+)
SPRET/EiJ ENSMSPG00010016357
 protein coding gene Chr3:78363873-78544706 (+)
WSB/EiJ ENSIUOG00005003008
 protein coding gene Chr3:78234648-78416559 (+)



Homology
more
  • Human Ortholog
    PDGFC, platelet derived growth factor C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFC, platelet derived growth factor C
  • Synonyms
    FALLOTEIN, SCDGF
  • Links
    NCBI Gene ID: 56034
    UniProt: Q9NRA1

  • Chr Location
    4q32.1; chr4:156760454-156971799 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1153
  • Tissues
    213
  • cDNA Data
    17
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54635 NCBI Gene Model | MGI Sequence Detail 177625 C57BL/6J ±  kb
    transcript NM_001357746 RefSeq | MGI Sequence Detail 3596 C57BL/6  
    polypeptide Q8CI19 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 17
      Primer pair 3
      Other 3
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916128, MGI:2139772
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 37
      Diseases 1
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
    • Latest
      J:388914 Thompson SM, et al., Rete ridges form via evolutionarily distinct mechanisms in mammalian skin. Nature. 2026 Mar;651(8104):135-145
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory