Atxn10 MGI Mouse Gene Detail - MGI:1859293

Symbol

Atxn10
Name

ataxin 10
Synonyms

E46, Sca10, TEG-169, Tex169

Feature Type

protein coding gene
IDs

MGI:1859293
NCBI Gene: 54138
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr15:85220446-85347413 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.32 cM
Mapping Data

2 experiments

SNPs within 2kb

2690 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859293	protein coding gene	Chr15:85220446-85348038 (+)
129S1/SvImJ	ENSMUSG00200034030	protein coding gene	Chr15:82346489-82473481 (+)
A/J	ENSMUSG00195016206	protein coding gene	Chr15:82272845-82399824 (+)
AKR/J	ENSMUSG00220026095	protein coding gene	Chr15:82326247-82453258 (+)
BALB/cJ	ENSMUSG00180014461	protein coding gene	Chr15:82149643-82276631 (+)
C3H/HeJ	ENSMUSG00175027088	protein coding gene	Chr15:82460481-82587468 (+)
C57BL/6NJ	ENSMUSG00215028518	protein coding gene	Chr15:82239423-82366393 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020126	protein coding gene	Chr15:79326866-79452277 (+)
CAST/EiJ	ENSTCUG00005026979	protein coding gene	Chr15:81738382-81865572 (+)
CBA/J	ENSMUSG00210013094	protein coding gene	Chr15:82235386-82362363 (+)
DBA/2J	ENSMUSG00185021979	protein coding gene	Chr15:82261287-82387993 (+)
FVB/NJ	ENSMUSG00205030382	protein coding gene	Chr15:82021707-82148695 (+)
JF1/MsJ	ENSUMUG00000022998	protein coding gene	Chr15:81780341-81906755 (+)
LP/J	ENSMUSG00230040325	protein coding gene	Chr15:85586688-85713678 (+)
NOD/ShiLtJ	ENSMUSG00190021688	protein coding gene	Chr15:82259091-82386067 (+)
NZO/HlLtJ	ENSMUSG00225048638	protein coding gene	Chr15:85925832-86052547 (+)
PWK/PhJ	ENSLUMG00010028821	protein coding gene	Chr15:81987461-82113877 (+)
SPRET/EiJ	ENSMSPG00010012342	protein coding gene	Chr15:83637464-83763434 (+)
WSB/EiJ	ENSIUOG00005010536	protein coding gene	Chr15:82326795-82453532 (+)

Human Ortholog

ATXN10, ataxin 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATXN10, ataxin 10
Synonyms

ATX10, E46L, HUMEEP, SCA10
Links

HGNC:10549

NCBI Gene ID: 25814

UniProt: Q9UBB4
Chr Location

22q13.31; chr22:45671798-45845307 (+) GRCh38

MGI Vertebrate Homology

Atxn10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATXN10
Gene Tree

Atxn10

Diseases

1 with human ATXN10 associations

				Human Disease	Mouse Models
				spinocerebellar ataxia 10 IDs spinocerebellar ataxia 10 DOID:0050960 OMIM:603516

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 3 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

20
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Atxn10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Homozygous null mice die at early postimplantation stages.

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All GO Annotations

39
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

34
cDNA Data

23
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atxn10

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All Sequences

62
RefSeq

2
UniProt

6
CCDS

CCDS37170.1

Ensembl

ENSMUSG00000016541 (Evidence)
NCBI Gene

54138

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016541	Ensembl Gene Model \| MGI Sequence Detail	126968	C57BL/6J	± kb
transcript	ENSMUST00000163242	Ensembl \| MGI Sequence Detail	1937	Not Applicable
polypeptide	ENSMUSP00000132450	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004504 ataxin-10

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR051374 Ataxin-10 and Copper transport protein 86 families

IPR019156 Ataxin-10 domain
GlyGen

P28658 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 24

Antibodies 1

Microarray probesets 7

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MGI:1096568, MGI:2145984, MGI:2146273

Summaries

All 77

Developmental Gene Expression 5

Diseases 1

Gene Ontology 9

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Atxn10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132507	Chr15:85220422-85220433 (+)	-18 bp
Tssr132508	Chr15:85220438-85220479 (+)	13 bp
Tssr132509	Chr15:85220488-85220504 (+)	50 bp
Tssr132510	Chr15:85220538-85220545 (+)	96 bp
Tssr132511	Chr15:85220551-85220588 (+)	124 bp
Tssr132512	Chr15:85220602-85220618 (+)	164 bp
Tssr132513	Chr15:85220645-85220661 (+)	207 bp
Tssr132514	Chr15:85238519-85238521 (+)	18,074 bp
Tssr132515	Chr15:85277635-85277651 (+)	57,197 bp
Tssr132516	Chr15:85286297-85286322 (+)	65,864 bp
Tssr132518	Chr15:85346326-85346371 (+)	125,903 bp
Tssr132519	Chr15:85346941-85346942 (+)	126,496 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24