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Dctn3 Gene Detail
Summary
  • Symbol
    Dctn3
  • Name
    dynactin 3
  • Synonyms
    p24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859251
    NCBI Gene: 53598
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41714798-41723170 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 21.98 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859251
 protein coding gene Chr4:41714798-41723213 (-)
129S1/SvImJ ENSMUSG00200003958
 protein coding gene Chr4:38562387-38570759 (-)
A/J ENSMUSG00195003086
 protein coding gene Chr4:38933069-38941460 (-)
AKR/J ENSMUSG00220031169
 protein coding gene Chr4:38761888-38770276 (-)
BALB/cJ ENSMUSG00180024032
 protein coding gene Chr4:38519888-38528277 (-)
C3H/HeJ ENSMUSG00175022425
 protein coding gene Chr4:38898488-38906876 (-)
C57BL/6NJ ENSMUSG00215014436
 protein coding gene Chr4:38536102-38544475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025920
 protein coding gene Chr4:35815676-35823710 (-)
CAST/EiJ ENSTCUG00005004105
 protein coding gene Chr4:38396225-38404611 (-)
CBA/J ENSMUSG00210007049
 protein coding gene Chr4:38599373-38607763 (-)
DBA/2J ENSMUSG00185006170
 protein coding gene Chr4:38673171-38681562 (-)
FVB/NJ ENSMUSG00205017476
 protein coding gene Chr4:38224029-38232422 (-)
JF1/MsJ ENSUMUG00000010609
 protein coding gene Chr4:38618329-38626769 (-)
LP/J ENSMUSG00230039616
 protein coding gene Chr4:42055918-42064290 (-)
NOD/ShiLtJ ENSMUSG00190005491
 protein coding gene Chr4:38623113-38631501 (-)
NZO/HlLtJ ENSMUSG00225006947
 protein coding gene Chr4:45932132-45940520 (-)
PWK/PhJ ENSLUMG00010006138
 protein coding gene Chr4:38172503-38180947 (-)
SPRET/EiJ ENSMSPG00010023567
 protein coding gene Chr4:39123713-39132114 (-)
WSB/EiJ ENSIUOG00005047321
 protein coding gene Chr4:38478811-38487187 (-)



Homology
more
  • Human Ortholog
    DCTN3, dynactin subunit 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCTN3, dynactin subunit 3
  • Synonyms
    DCTN-22, DCTN22
  • Links
    NCBI Gene ID: 11258
    UniProt: O75935

  • Chr Location
    9p13.3; chr9:34613545-34620523 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    6
  • Chemically and radiation induced
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Dctn3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    101
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028447 Ensembl Gene Model | MGI Sequence Detail 8373 C57BL/6J ±  kb
transcript ENSMUST00000030158 Ensembl | MGI Sequence Detail 973 Not Applicable  
polypeptide ENSMUSP00000030158 Ensembl | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    cDNA 101

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:62147 Pfister KK, et al., Identification and molecular characterization of the p24 dynactin light chain. Cell Motil Cytoskeleton. 1998;41(2):154-67
  • Latest
    J:339244 Chen X, et al., Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Cell Biosci. 2022 Jul 6;12(1):103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory