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Ddah2 Gene Detail
Summary
  • Symbol
    Ddah2
  • Name
    DDAH family member 2, ADMA independent
  • Synonyms
    Clone 7u, Ddah, G6a, NG30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859016
    NCBI Gene: 51793
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35278011-35281071 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859016
 protein coding gene Chr17:35278011-35281075 (+)
129S1/SvImJ ENSMUSG00200050592
 protein coding gene Chr17:30982132-30985192 (+)
A/J ENSMUSG00195039505
 protein coding gene Chr17:31882097-31885157 (+)
AKR/J ENSMUSG00220050922
 protein coding gene Chr17:30910977-30914037 (+)
BALB/cJ ENSMUSG00180035047
 protein coding gene Chr17:31251958-31255018 (+)
C3H/HeJ ENSMUSG00175032434
 protein coding gene Chr17:30797094-30800154 (+)
C57BL/6NJ ENSMUSG00215051981
 protein coding gene Chr17:30822343-30825403 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021496
 protein coding gene Chr17:31800036-31802849 (+)
CAST/EiJ ENSTCUG00005049441
 protein coding gene Chr17:31839784-31842844 (+)
CBA/J ENSMUSG00210049129
 protein coding gene Chr17:30619186-30622246 (+)
DBA/2J ENSMUSG00185045030
 protein coding gene Chr17:33271210-33274270 (+)
FVB/NJ ENSMUSG00205036351
 protein coding gene Chr17:31139610-31142670 (+)
JF1/MsJ ENSUMUG00000056947
 protein coding gene Chr17:32523644-32526704 (+)
LP/J ENSMUSG00230054629
 protein coding gene Chr17:34380385-34383445 (+)
NOD/ShiLtJ ENSMUSG00190052604
 protein coding gene Chr17:30740934-30743994 (+)
NZO/HlLtJ ENSMUSG00225054285
 protein coding gene Chr17:36392611-36395671 (+)
PWK/PhJ ENSLUMG00010038616
 protein coding gene Chr17:30358827-30361887 (+)
SPRET/EiJ ENSMSPG00010034266
 protein coding gene Chr17:31542746-31545803 (+)
WSB/EiJ ENSIUOG00005045246
 protein coding gene Chr17:31468122-31471182 (+)



Homology
more
  • Human Ortholog
    DDAH2, DDAH family member 2, ADMA-independent
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDAH2, DDAH family member 2, ADMA-independent
  • Synonyms
    DDAH, DDAHII, G6a, HEL-S-277, NG30
  • Links
    NCBI Gene ID: 23564
    UniProt: O95865

  • Chr Location
    6p21.33; chr6:31727038-31730617 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice exhibit normal embryonic survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    106
  • cDNA Data
    162
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007039 Ensembl Gene Model | MGI Sequence Detail 3061 C57BL/6J ±  kb
transcript ENSMUST00000007255 Ensembl | MGI Sequence Detail 1342 Not Applicable  
polypeptide ENSMUSP00000007255 Ensembl | MGI Sequence Detail 285 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006339 putative hydrolase DDAH2
    (term hierarchy)
  • EC
    3.-.-.-
  • InterPro Domains
    IPR033199 Dimethylarginine dimethylaminohydrolase-like
  • GlyGen
    Q99LD8 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
Molecular
Reagents
less
  • All nucleic 163
    Genomic 1
    cDNA 162
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146979, MGI:2147062
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:44498 Spanjaard RA, et al., Clone 10d/BM28 (CDCL1), an early S-phase protein, is an important growth regulator of melanoma. Cancer Res. 1997 Nov 15;57(22):5122-8
  • Latest
    J:341706 Wu Y, et al., Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis. Sci Adv. 2023 Feb 10;9(6):eade5584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory