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Semg1 Gene Detail
Summary
  • Symbol
    Semg1
  • Name
    semenogelin 1
  • Synonyms
    semenoclotin, Svs2, SVS II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858275
    NCBI Gene: 53878
  • Alliance
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164077849-164080261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 84.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858275
protein coding gene Chr2:164077849-164080386 (-)
129S1/SvImJ ENSMUSG00200016414
protein coding gene Chr2:160951286-160953832 (-)
A/J ENSMUSG00195017816
protein coding gene Chr2:161291453-161293990 (-)
AKR/J ENSMUSG00220013381
protein coding gene Chr2:160618899-160621436 (-)
BALB/cJ ENSMUSG00180044703
protein coding gene Chr2:160745201-160747738 (-)
C3H/HeJ ENSMUSG00175046868
protein coding gene Chr2:161494979-161497516 (-)
C57BL/6NJ ENSMUSG00215028989
protein coding gene Chr2:160948205-160950742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024636
protein coding gene Chr2:156173929-156177175 (-)
CAST/EiJ ENSTCUG00005044745
protein coding gene Chr2:159872228-159874771 (-)
CBA/J ENSMUSG00210015565
protein coding gene Chr2:161425942-161428479 (-)
DBA/2J ENSMUSG00185045495
protein coding gene Chr2:161162186-161164723 (-)
FVB/NJ ENSMUSG00205025792
protein coding gene Chr2:160183358-160185895 (-)
JF1/MsJ ENSUMUG00000009975
protein coding gene Chr2:160811127-160813669 (-)
LP/J ENSMUSG00230045082
protein coding gene Chr2:162720897-162723443 (-)
NOD/ShiLtJ ENSMUSG00190041529
protein coding gene Chr2:160830727-160833280 (-)
NZO/HlLtJ ENSMUSG00225051446
protein coding gene Chr2:170724532-170727069 (-)
PWK/PhJ ENSLUMG00010044988
protein coding gene Chr2:160714832-160717377 (-)
SPRET/EiJ ENSMSPG00010032596
protein coding gene Chr2:163483716-163485580 (-)
WSB/EiJ ENSIUOG00005040888
protein coding gene Chr2:160558025-160560562 (-)



Homology
more
  • Human Ortholog
    SEMG1, semenogelin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMG1, semenogelin 1
  • Synonyms
    CT103, dJ172H20.2, SEMG, SGI
  • Links
    NCBI Gene ID: 6406
    UniProt: P04279

  • Chr Location
    20q13.12; chr20:45207033-45210605 (+)  GRCh38

  • Human Ortholog
    SEMG2, semenogelin 2
  • Synonyms
    SGII
  • Links
    NCBI Gene ID: 6407
    UniProt: Q02383

  • Chr Location
    20q13.12; chr20:45221373-45224458 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele display severely reduced fertility with premature acrosome reaction, absence of copulatory plug formation and intrauterine death of sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53878 NCBI Gene Model | MGI Sequence Detail 2413 C57BL/6J ±  kb
    transcript NM_017390 RefSeq | MGI Sequence Detail 1570 ZRU/MplStud  
    polypeptide NP_059086 RefSeq | MGI Sequence Detail 375 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR008836 Semenogelin
      IPR002080 Seminal vesicle protein II, conserved site
      IPR018942 Seminal vesicle protein repeat
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139431, MGI:6718886
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:31528 Lundwall A, The cloning of a rapidly evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semen. Eur J Biochem. 1996 Jan 15;235(1-2):424-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/01/2026
    MGI 6.24
    The Jackson Laboratory