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Pcdh12 Gene Detail
Summary
  • Symbol
    Pcdh12
  • Name
    protocadherin 12
  • Synonyms
    vascular endothelial cadherin-2, VE-cadherin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855700
    NCBI Gene: 53601
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38400145-38417454 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 20.17 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855700
 protein coding gene Chr18:38400142-38417455 (-)
129S1/SvImJ ENSMUSG00200041460
 protein coding gene Chr18:35397685-35414739 (-)
A/J ENSMUSG00195032884
 protein coding gene Chr18:35550281-35567333 (-)
AKR/J ENSMUSG00220016281
 protein coding gene Chr18:35518326-35535376 (-)
BALB/cJ ENSMUSG00180018373
 protein coding gene Chr18:35999910-36016961 (-)
C3H/HeJ ENSMUSG00175037625
 protein coding gene Chr18:35512607-35529951 (-)
C57BL/6NJ ENSMUSG00215010989
 protein coding gene Chr18:35269785-35287102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022209
 protein coding gene Chr18:35458500-35475795 (-)
CAST/EiJ ENSTCUG00005020497
 protein coding gene Chr18:35129023-35146489 (-)
CBA/J ENSMUSG00210020298
 protein coding gene Chr18:35541934-35558985 (-)
DBA/2J ENSMUSG00185018656
 protein coding gene Chr18:35476520-35493570 (-)
FVB/NJ ENSMUSG00205015346
 protein coding gene Chr18:35176618-35193675 (-)
JF1/MsJ ENSUMUG00000025392
 protein coding gene Chr18:35607620-35625239 (-)
LP/J ENSMUSG00230046117
 protein coding gene Chr18:37591803-37608853 (-)
NOD/ShiLtJ ENSMUSG00190017114
 protein coding gene Chr18:35260928-35278272 (-)
NZO/HlLtJ ENSMUSG00225044132
 protein coding gene Chr18:37498457-37515797 (-)
PWK/PhJ ENSLUMG00010010990
 protein coding gene Chr18:35756430-35774048 (-)
SPRET/EiJ ENSMSPG00010020776
 protein coding gene Chr18:35787809-35805360 (-)
WSB/EiJ ENSIUOG00005007066
 protein coding gene Chr18:35256278-35273632 (-)



Homology
more
  • Human Ortholog
    PCDH12, protocadherin 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDH12, protocadherin 12
  • Synonyms
    DMJDS1, VECAD2, VE-cadherin-2
  • Links
    NCBI Gene ID: 51294
    UniProt: Q9NPG4

  • Chr Location
    5q31.3; chr5:141943581-141969741 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable, fertile and do not display any obvious histomorphological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    682
  • Tissues
    52
  • cDNA Data
    32
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53601 NCBI Gene Model | MGI Sequence Detail 17310 C57BL/6J ±  kb
    transcript NM_017378 RefSeq | MGI Sequence Detail 5587 C57BL/6  
    polypeptide O55134 UniProt | EBI | MGI Sequence Detail 1180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 34
      Primer pair 4
      Other 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 38
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:48727 Telo' P, et al., Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells. J Biol Chem. 1998 Jul 10;273(28):17565-72
    • Latest
      J:372013 Mincheva-Tasheva S, et al., Mapping combinatorial expression of non-clustered protocadherins in the developing brain identifies novel PCDH19-mediated cell adhesion properties. Open Biol. 2024 Apr;14(4):230383
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory