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Grb14 Gene Detail
Summary
  • Symbol
    Grb14
  • Name
    growth factor receptor bound protein 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355324
    NCBI Gene: 50915
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:64742820-64853143 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 38.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3183 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355324
 protein coding gene Chr2:64742820-64855331 (-)
129S1/SvImJ ENSMUSG00200036536
 protein coding gene Chr2:61810719-61922121 (-)
A/J ENSMUSG00195022533
 protein coding gene Chr2:61944168-62055701 (-)
AKR/J ENSMUSG00220035896
 protein coding gene Chr2:61896665-62008192 (-)
BALB/cJ ENSMUSG00180041247
 protein coding gene Chr2:61889587-62001120 (-)
C3H/HeJ ENSMUSG00175033451
 protein coding gene Chr2:61954773-62066293 (-)
C57BL/6NJ ENSMUSG00215015942
 protein coding gene Chr2:61835475-61946997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023598
 protein coding gene Chr2:59576533-59687401 (-)
CAST/EiJ ENSTCUG00005008672
 protein coding gene Chr2:61230479-61341530 (-)
CBA/J ENSMUSG00210030870
 protein coding gene Chr2:61992182-62103700 (-)
DBA/2J ENSMUSG00185038455
 protein coding gene Chr2:61858496-61969942 (-)
FVB/NJ ENSMUSG00205033306
 protein coding gene Chr2:61378156-61495078 (-)
JF1/MsJ ENSUMUG00000004751
 protein coding gene Chr2:61521914-61631180 (-)
LP/J ENSMUSG00230021105
 protein coding gene Chr2:63697434-63808941 (-)
NOD/ShiLtJ ENSMUSG00190026426
 protein coding gene Chr2:61933107-62050020 (-)
NZO/HlLtJ ENSMUSG00225000323
 protein coding gene Chr2:71426722-71538235 (-)
PWK/PhJ ENSLUMG00010031475
 protein coding gene Chr2:61688282-61799333 (-)
SPRET/EiJ ENSMSPG00010032461
 protein coding gene Chr2:62965847-63077530 (-)
WSB/EiJ ENSIUOG00005018536
 protein coding gene Chr2:61985928-62098232 (-)



Homology
more
  • Human Ortholog
    GRB14, growth factor receptor bound protein 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRB14, growth factor receptor bound protein 14
  • Links
    NCBI Gene ID: 2888
    UniProt: Q14449

  • Chr Location
    2q24.3; chr2:164492417-164622472 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRB14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in improved glucose tolerance, lower circulating insulin levels and increased incorporation of glucose into glycogen in the liver and skeletal muscle of males. Both males and females exhibit a decrease in body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    38
  • cDNA Data
    25
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50915 NCBI Gene Model | MGI Sequence Detail 110324 C57BL/6J ±  kb
    transcript NM_016719 RefSeq | MGI Sequence Detail 2003 C57BL/6  
    polypeptide Q9JLM9 UniProt | EBI | MGI Sequence Detail 538 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138995
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:200516 Jones N, et al., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905
    • Latest
      J:355260 Moorwood K, et al., Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism. BMC Biol. 2024 Sep 30;22(1):221
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory