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Scly Gene Detail
Summary
  • Symbol
    Scly
  • Name
    selenocysteine lyase
  • Synonyms
    A930015N15Rik, SCL, Scly1, Scly2, Selenocysteine reductase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355310
    NCBI Gene: 50880
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91226060-91248797 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    749 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355310
 protein coding gene Chr1:91226017-91248797 (+)
129S1/SvImJ ENSMUSG00200035912
 protein coding gene Chr1:88452282-88475008 (+)
A/J ENSMUSG00195027456
 protein coding gene Chr1:88004220-88026936 (+)
AKR/J ENSMUSG00220043819
 protein coding gene Chr1:88161643-88184363 (+)
BALB/cJ ENSMUSG00180016521
 protein coding gene Chr1:88318665-88341413 (+)
C3H/HeJ ENSMUSG00175001290
 protein coding gene Chr1:88190073-88212785 (+)
C57BL/6NJ ENSMUSG00215017401
 protein coding gene Chr1:88126495-88149261 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014418
 protein coding gene Chr1:83749011-83771694 (+)
CAST/EiJ ENSTCUG00005007365
 protein coding gene Chr1:87755575-87783356 (+)
CBA/J ENSMUSG00210011615
 protein coding gene Chr1:88035348-88058060 (+)
DBA/2J ENSMUSG00185013537
 protein coding gene Chr1:92505055-92527798 (+)
FVB/NJ ENSMUSG00205019845
 protein coding gene Chr1:87449685-87472406 (+)
JF1/MsJ ENSUMUG00000016666
 protein coding gene Chr1:91245531-91273184 (+)
LP/J ENSMUSG00230019087
 protein coding gene Chr1:91788439-91811163 (+)
NOD/ShiLtJ ENSMUSG00190024506
 protein coding gene Chr1:88086284-88109026 (+)
NZO/HlLtJ ENSMUSG00225002463
 protein coding gene Chr1:95689841-95712565 (+)
PWK/PhJ ENSLUMG00010037940
 protein coding gene Chr1:87637648-87665691 (+)
SPRET/EiJ ENSMSPG00010041335
 protein coding gene Chr1:89674836-89697272 (+)
WSB/EiJ ENSIUOG00005036538
 protein coding gene Chr1:87748903-87771635 (+)



Homology
more
  • Human Ortholog
    SCLY, selenocysteine lyase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCLY, selenocysteine lyase
  • Synonyms
    hSCL, SCL
  • Links
    NCBI Gene ID: 51540
    UniProt: Q96I15

  • Chr Location
    2q37.3; chr2:238060924-238099413 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice fed a selenium-deficient diet exhibit mild learning impairment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026307 Ensembl Gene Model | MGI Sequence Detail 22738 C57BL/6J ±  kb
transcript ENSMUST00000027532 Ensembl | MGI Sequence Detail 2202 Not Applicable  
polypeptide ENSMUSP00000027532 Ensembl | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925207
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory